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A MOUSE MODEL OF MAMMARY HYPERPLASIA INDUCED BY ORAL HORMONE ADMINISTRATION
BACKGROUND: Mammary hyperplasia is one of the most common benign breast disorders. Although traditional Chinese medicine has a vast experience in the treatment of mammary hyperplasia, it is not accepted widely due to its unclear mechanism. METHODS AND MATERIALS: To address the mechanism, we develope...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
African Traditional Herbal Medicine Supporters Initiative (ATHMSI)
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471472/ https://www.ncbi.nlm.nih.gov/pubmed/28638887 http://dx.doi.org/10.21010/ajtcam.v14i4.27 |
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author | Sun, Li Guo, Dong-Hui Liu, Fei Liu, Qian Jiang, Ning Sun, Yun-Feng Cai, Li-Ping Zheng, Hong-Xin |
author_facet | Sun, Li Guo, Dong-Hui Liu, Fei Liu, Qian Jiang, Ning Sun, Yun-Feng Cai, Li-Ping Zheng, Hong-Xin |
author_sort | Sun, Li |
collection | PubMed |
description | BACKGROUND: Mammary hyperplasia is one of the most common benign breast disorders. Although traditional Chinese medicine has a vast experience in the treatment of mammary hyperplasia, it is not accepted widely due to its unclear mechanism. METHODS AND MATERIALS: To address the mechanism, we developed a mouse model of mammary hyperplasia. We gave mice estradiol valerate tablets and progesterone capsules sequentially for one month by intragastric administration. RESULTS: Mice treated by this method had a series of pathological changes which are similar to those detected in women with mammary hyperplasia, including ectopic level of estradiol and progesterone in serum, hyperplasia of mammary glands and increased expression of ERα and PR. CONCLUSION: This model will facilitate the mechanical study of traditional medicine on mammary hyperplasia. |
format | Online Article Text |
id | pubmed-5471472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | African Traditional Herbal Medicine Supporters Initiative (ATHMSI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-54714722017-06-21 A MOUSE MODEL OF MAMMARY HYPERPLASIA INDUCED BY ORAL HORMONE ADMINISTRATION Sun, Li Guo, Dong-Hui Liu, Fei Liu, Qian Jiang, Ning Sun, Yun-Feng Cai, Li-Ping Zheng, Hong-Xin Afr J Tradit Complement Altern Med Article BACKGROUND: Mammary hyperplasia is one of the most common benign breast disorders. Although traditional Chinese medicine has a vast experience in the treatment of mammary hyperplasia, it is not accepted widely due to its unclear mechanism. METHODS AND MATERIALS: To address the mechanism, we developed a mouse model of mammary hyperplasia. We gave mice estradiol valerate tablets and progesterone capsules sequentially for one month by intragastric administration. RESULTS: Mice treated by this method had a series of pathological changes which are similar to those detected in women with mammary hyperplasia, including ectopic level of estradiol and progesterone in serum, hyperplasia of mammary glands and increased expression of ERα and PR. CONCLUSION: This model will facilitate the mechanical study of traditional medicine on mammary hyperplasia. African Traditional Herbal Medicine Supporters Initiative (ATHMSI) 2017-06-05 /pmc/articles/PMC5471472/ /pubmed/28638887 http://dx.doi.org/10.21010/ajtcam.v14i4.27 Text en Copyright: © 2017 Afr. J. Traditional Complementary and Alternative Medicines http://creativecommons.org/licenses/CC-BY/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License |
spellingShingle | Article Sun, Li Guo, Dong-Hui Liu, Fei Liu, Qian Jiang, Ning Sun, Yun-Feng Cai, Li-Ping Zheng, Hong-Xin A MOUSE MODEL OF MAMMARY HYPERPLASIA INDUCED BY ORAL HORMONE ADMINISTRATION |
title | A MOUSE MODEL OF MAMMARY HYPERPLASIA INDUCED BY ORAL HORMONE ADMINISTRATION |
title_full | A MOUSE MODEL OF MAMMARY HYPERPLASIA INDUCED BY ORAL HORMONE ADMINISTRATION |
title_fullStr | A MOUSE MODEL OF MAMMARY HYPERPLASIA INDUCED BY ORAL HORMONE ADMINISTRATION |
title_full_unstemmed | A MOUSE MODEL OF MAMMARY HYPERPLASIA INDUCED BY ORAL HORMONE ADMINISTRATION |
title_short | A MOUSE MODEL OF MAMMARY HYPERPLASIA INDUCED BY ORAL HORMONE ADMINISTRATION |
title_sort | mouse model of mammary hyperplasia induced by oral hormone administration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471472/ https://www.ncbi.nlm.nih.gov/pubmed/28638887 http://dx.doi.org/10.21010/ajtcam.v14i4.27 |
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