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Neuroprotection and Stroke Rehabilitation: Modulation and Enhancement of Recovery

Recent advances in research are modifying our view of recovery after nervous system damage. New findings are changing previously held concepts and providing promising avenues for treatment of patients after stroke. This review discusses mechanisms of neuronal injury after brain ischemia and the atte...

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Detalles Bibliográficos
Autores principales: Romero, José Rafael, Babikian, Viken L., Katz, Douglas I., Finklestein, Seth P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471540/
https://www.ncbi.nlm.nih.gov/pubmed/16720957
http://dx.doi.org/10.1155/2006/137532
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author Romero, José Rafael
Babikian, Viken L.
Katz, Douglas I.
Finklestein, Seth P.
author_facet Romero, José Rafael
Babikian, Viken L.
Katz, Douglas I.
Finklestein, Seth P.
author_sort Romero, José Rafael
collection PubMed
description Recent advances in research are modifying our view of recovery after nervous system damage. New findings are changing previously held concepts and providing promising avenues for treatment of patients after stroke. This review discusses mechanisms of neuronal injury after brain ischemia and the attempts to study neuroprotection options based on such mechanisms. It also considers measures available at present to improve outcome after stroke and presents new areas of research, particularly stimulation techniques, neurogenesis and trophic factors to enhance recovery. In order to improve outcomes, medications that may be detrimental to recovery should be avoided, while symptomatic therapy of problems such as depression, pain syndromes and spasticity may contribute to better results. Continued surveillance and early treatment of complications associated with acute stroke, along with supportive care remain the mainstay of treatment for stroke patients in the recovery phase. Present research on limiting brain damage and improving recovery and plasticity enhance the prospects for better clinical treatments to improve recovery after stroke.
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spelling pubmed-54715402017-07-02 Neuroprotection and Stroke Rehabilitation: Modulation and Enhancement of Recovery Romero, José Rafael Babikian, Viken L. Katz, Douglas I. Finklestein, Seth P. Behav Neurol Research Article Recent advances in research are modifying our view of recovery after nervous system damage. New findings are changing previously held concepts and providing promising avenues for treatment of patients after stroke. This review discusses mechanisms of neuronal injury after brain ischemia and the attempts to study neuroprotection options based on such mechanisms. It also considers measures available at present to improve outcome after stroke and presents new areas of research, particularly stimulation techniques, neurogenesis and trophic factors to enhance recovery. In order to improve outcomes, medications that may be detrimental to recovery should be avoided, while symptomatic therapy of problems such as depression, pain syndromes and spasticity may contribute to better results. Continued surveillance and early treatment of complications associated with acute stroke, along with supportive care remain the mainstay of treatment for stroke patients in the recovery phase. Present research on limiting brain damage and improving recovery and plasticity enhance the prospects for better clinical treatments to improve recovery after stroke. IOS Press 2006 2006-05-11 /pmc/articles/PMC5471540/ /pubmed/16720957 http://dx.doi.org/10.1155/2006/137532 Text en Copyright © 2006 Hindawi Publishing Corporation and the authors. http://creativecommons.org/licenses/by/3.0 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Romero, José Rafael
Babikian, Viken L.
Katz, Douglas I.
Finklestein, Seth P.
Neuroprotection and Stroke Rehabilitation: Modulation and Enhancement of Recovery
title Neuroprotection and Stroke Rehabilitation: Modulation and Enhancement of Recovery
title_full Neuroprotection and Stroke Rehabilitation: Modulation and Enhancement of Recovery
title_fullStr Neuroprotection and Stroke Rehabilitation: Modulation and Enhancement of Recovery
title_full_unstemmed Neuroprotection and Stroke Rehabilitation: Modulation and Enhancement of Recovery
title_short Neuroprotection and Stroke Rehabilitation: Modulation and Enhancement of Recovery
title_sort neuroprotection and stroke rehabilitation: modulation and enhancement of recovery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471540/
https://www.ncbi.nlm.nih.gov/pubmed/16720957
http://dx.doi.org/10.1155/2006/137532
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