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Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle

Mitochondria are characterized by its pivotal roles in managing energy production, reactive oxygen species, and calcium, whose aging-related structural and functional deteriorations are observed in aging muscle. Although it is still unclear how aging alters mitochondrial quality and quantity in skel...

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Detalles Bibliográficos
Autores principales: Kim, Yuho, Triolo, Matthew, Hood, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471566/
https://www.ncbi.nlm.nih.gov/pubmed/28656072
http://dx.doi.org/10.1155/2017/3165396
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author Kim, Yuho
Triolo, Matthew
Hood, David A.
author_facet Kim, Yuho
Triolo, Matthew
Hood, David A.
author_sort Kim, Yuho
collection PubMed
description Mitochondria are characterized by its pivotal roles in managing energy production, reactive oxygen species, and calcium, whose aging-related structural and functional deteriorations are observed in aging muscle. Although it is still unclear how aging alters mitochondrial quality and quantity in skeletal muscle, dysregulation of mitochondrial biogenesis and dynamic controls has been suggested as key players for that. In this paper, we summarize current understandings on how aging regulates muscle mitochondrial biogenesis, while focusing on transcriptional regulations including PGC-1α, AMPK, p53, mtDNA, and Tfam. Further, we review current findings on the muscle mitochondrial dynamic systems in aging muscle: fusion/fission, autophagy/mitophagy, and protein import. Next, we also discuss how endurance and resistance exercises impact on the mitochondrial quality controls in aging muscle, suggesting possible effective exercise strategies to improve/maintain mitochondrial health.
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spelling pubmed-54715662017-06-27 Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle Kim, Yuho Triolo, Matthew Hood, David A. Oxid Med Cell Longev Review Article Mitochondria are characterized by its pivotal roles in managing energy production, reactive oxygen species, and calcium, whose aging-related structural and functional deteriorations are observed in aging muscle. Although it is still unclear how aging alters mitochondrial quality and quantity in skeletal muscle, dysregulation of mitochondrial biogenesis and dynamic controls has been suggested as key players for that. In this paper, we summarize current understandings on how aging regulates muscle mitochondrial biogenesis, while focusing on transcriptional regulations including PGC-1α, AMPK, p53, mtDNA, and Tfam. Further, we review current findings on the muscle mitochondrial dynamic systems in aging muscle: fusion/fission, autophagy/mitophagy, and protein import. Next, we also discuss how endurance and resistance exercises impact on the mitochondrial quality controls in aging muscle, suggesting possible effective exercise strategies to improve/maintain mitochondrial health. Hindawi 2017 2017-06-01 /pmc/articles/PMC5471566/ /pubmed/28656072 http://dx.doi.org/10.1155/2017/3165396 Text en Copyright © 2017 Yuho Kim et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Yuho
Triolo, Matthew
Hood, David A.
Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle
title Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle
title_full Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle
title_fullStr Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle
title_full_unstemmed Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle
title_short Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle
title_sort impact of aging and exercise on mitochondrial quality control in skeletal muscle
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471566/
https://www.ncbi.nlm.nih.gov/pubmed/28656072
http://dx.doi.org/10.1155/2017/3165396
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