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Pediatric Ovarian Growing Teratoma Syndrome

Ovarian immature teratoma is a germ cell tumor that comprises less than 1% of ovarian cancers and is treated with surgical debulking and chemotherapy depending on stage. Growing teratoma syndrome (GTS) is the phenomenon of the growth of mature teratoma elements with normal tumor markers during or fo...

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Autores principales: Rentea, Rebecca M., Varghese, Aaron, Ahmed, Atif, Kats, Alexander, Manalang, Michelle, Dowlut-McElroy, Tazim, Hendrickson, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471592/
https://www.ncbi.nlm.nih.gov/pubmed/28656118
http://dx.doi.org/10.1155/2017/3074240
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author Rentea, Rebecca M.
Varghese, Aaron
Ahmed, Atif
Kats, Alexander
Manalang, Michelle
Dowlut-McElroy, Tazim
Hendrickson, Richard J.
author_facet Rentea, Rebecca M.
Varghese, Aaron
Ahmed, Atif
Kats, Alexander
Manalang, Michelle
Dowlut-McElroy, Tazim
Hendrickson, Richard J.
author_sort Rentea, Rebecca M.
collection PubMed
description Ovarian immature teratoma is a germ cell tumor that comprises less than 1% of ovarian cancers and is treated with surgical debulking and chemotherapy depending on stage. Growing teratoma syndrome (GTS) is the phenomenon of the growth of mature teratoma elements with normal tumor markers during or following chemotherapy for treatment of a malignant germ cell tumor. These tumors are associated with significant morbidity and mortality due to invasive and compressive growth as well as potential for malignant transformation. Current treatment modality is surgical resection. We discuss a 12-year-old female who presented following resection of a pure ovarian immature teratoma (grade 3, FIGO stage IIIC). Following chemotherapy and resection of a pelvic/liver recurrence demonstrating mature teratoma, she underwent molecular genetics based chemotherapeutic treatment. No standardized management protocol has been established for the treatment of GTS. The effect of chemotherapeutic agents for decreasing the volume of and prevention of expansion is unknown. We review in detail the history, diagnostic algorithm, and previous reported pediatric cases as well as treatment options for pediatric patients with GTS.
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spelling pubmed-54715922017-06-27 Pediatric Ovarian Growing Teratoma Syndrome Rentea, Rebecca M. Varghese, Aaron Ahmed, Atif Kats, Alexander Manalang, Michelle Dowlut-McElroy, Tazim Hendrickson, Richard J. Case Rep Surg Case Report Ovarian immature teratoma is a germ cell tumor that comprises less than 1% of ovarian cancers and is treated with surgical debulking and chemotherapy depending on stage. Growing teratoma syndrome (GTS) is the phenomenon of the growth of mature teratoma elements with normal tumor markers during or following chemotherapy for treatment of a malignant germ cell tumor. These tumors are associated with significant morbidity and mortality due to invasive and compressive growth as well as potential for malignant transformation. Current treatment modality is surgical resection. We discuss a 12-year-old female who presented following resection of a pure ovarian immature teratoma (grade 3, FIGO stage IIIC). Following chemotherapy and resection of a pelvic/liver recurrence demonstrating mature teratoma, she underwent molecular genetics based chemotherapeutic treatment. No standardized management protocol has been established for the treatment of GTS. The effect of chemotherapeutic agents for decreasing the volume of and prevention of expansion is unknown. We review in detail the history, diagnostic algorithm, and previous reported pediatric cases as well as treatment options for pediatric patients with GTS. Hindawi 2017 2017-06-01 /pmc/articles/PMC5471592/ /pubmed/28656118 http://dx.doi.org/10.1155/2017/3074240 Text en Copyright © 2017 Rebecca M. Rentea et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Rentea, Rebecca M.
Varghese, Aaron
Ahmed, Atif
Kats, Alexander
Manalang, Michelle
Dowlut-McElroy, Tazim
Hendrickson, Richard J.
Pediatric Ovarian Growing Teratoma Syndrome
title Pediatric Ovarian Growing Teratoma Syndrome
title_full Pediatric Ovarian Growing Teratoma Syndrome
title_fullStr Pediatric Ovarian Growing Teratoma Syndrome
title_full_unstemmed Pediatric Ovarian Growing Teratoma Syndrome
title_short Pediatric Ovarian Growing Teratoma Syndrome
title_sort pediatric ovarian growing teratoma syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471592/
https://www.ncbi.nlm.nih.gov/pubmed/28656118
http://dx.doi.org/10.1155/2017/3074240
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