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Influence of Syrgical Trauma on Nitric Oxide and Nitrotyrosine Serum Levels in Patients Undergoing Laparoscopic Or Conventional Cholecystectomy

BACKGROUND: Oxidative stress represents tissue damage caused by reactive forms of oxygen and nitrogen due to the inability of antioxidant mechanisms to reduce reactive forms into more stable ones. The aim of the study was to evaluate the influence of surgical trauma on nitric oxide (NO) and nitrotyr...

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Autores principales: Mijatović, Srdjan, Alempijević, Tamara, Stefanović, Branislava, Jeremić, Vasilije, Krstić, Slobodan, Radmanović, Nikola, Jovanović, Sanja, Stefanović, Branislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Medical Biochemists of Serbia 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471650/
https://www.ncbi.nlm.nih.gov/pubmed/28680361
http://dx.doi.org/10.1515/jomb-2017-0004
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author Mijatović, Srdjan
Alempijević, Tamara
Stefanović, Branislava
Jeremić, Vasilije
Krstić, Slobodan
Radmanović, Nikola
Jovanović, Sanja
Stefanović, Branislav
author_facet Mijatović, Srdjan
Alempijević, Tamara
Stefanović, Branislava
Jeremić, Vasilije
Krstić, Slobodan
Radmanović, Nikola
Jovanović, Sanja
Stefanović, Branislav
author_sort Mijatović, Srdjan
collection PubMed
description BACKGROUND: Oxidative stress represents tissue damage caused by reactive forms of oxygen and nitrogen due to the inability of antioxidant mechanisms to reduce reactive forms into more stable ones. The aim of the study was to evaluate the influence of surgical trauma on nitric oxide (NO) and nitrotyrosine (NT) values in patients undergoing conventional and laparoscopic cholecystectomy. METHODS: A prospective study included sixty patients from the Department of Emergency Surgery, Clinical Centre of Serbia who were operated for gallstone related chronic cholecystitis. All the patients enrolled in the study underwent cholecystectomy; the first group was operated conventionally (30 patients – control group), while the second group was operated laparoscopically (30 patients – treatment group). RESULTS: There were no statistically significant differences in the values of NO and its postoperative changes in both groups, the conventionally operated group (p=0.943) and the laparoscopically operated group (p=0.393). We found an increase in NT values 24 hours postoperatively (p=0.000) in the conventionally operated patients, while in the group operated laparoscopically we didn’t find statistically significant changes in the values of NT (conventionally operated group (p=0.943) and laparoscopically operated group (p=0.393)). CONCLUSIONS: In our study, we found a significant increase in NT values 24 hours postoperatively in conventionally operated patients i.e. the control group, vs. the treatment group. Further randomized studies are needed for a better understanding of the impact of surgical trauma on oxidative stress response.
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spelling pubmed-54716502017-07-05 Influence of Syrgical Trauma on Nitric Oxide and Nitrotyrosine Serum Levels in Patients Undergoing Laparoscopic Or Conventional Cholecystectomy Mijatović, Srdjan Alempijević, Tamara Stefanović, Branislava Jeremić, Vasilije Krstić, Slobodan Radmanović, Nikola Jovanović, Sanja Stefanović, Branislav J Med Biochem Original Paper BACKGROUND: Oxidative stress represents tissue damage caused by reactive forms of oxygen and nitrogen due to the inability of antioxidant mechanisms to reduce reactive forms into more stable ones. The aim of the study was to evaluate the influence of surgical trauma on nitric oxide (NO) and nitrotyrosine (NT) values in patients undergoing conventional and laparoscopic cholecystectomy. METHODS: A prospective study included sixty patients from the Department of Emergency Surgery, Clinical Centre of Serbia who were operated for gallstone related chronic cholecystitis. All the patients enrolled in the study underwent cholecystectomy; the first group was operated conventionally (30 patients – control group), while the second group was operated laparoscopically (30 patients – treatment group). RESULTS: There were no statistically significant differences in the values of NO and its postoperative changes in both groups, the conventionally operated group (p=0.943) and the laparoscopically operated group (p=0.393). We found an increase in NT values 24 hours postoperatively (p=0.000) in the conventionally operated patients, while in the group operated laparoscopically we didn’t find statistically significant changes in the values of NT (conventionally operated group (p=0.943) and laparoscopically operated group (p=0.393)). CONCLUSIONS: In our study, we found a significant increase in NT values 24 hours postoperatively in conventionally operated patients i.e. the control group, vs. the treatment group. Further randomized studies are needed for a better understanding of the impact of surgical trauma on oxidative stress response. Society of Medical Biochemists of Serbia 2017-04-22 /pmc/articles/PMC5471650/ /pubmed/28680361 http://dx.doi.org/10.1515/jomb-2017-0004 Text en © by Srdjan Mijatović. http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
spellingShingle Original Paper
Mijatović, Srdjan
Alempijević, Tamara
Stefanović, Branislava
Jeremić, Vasilije
Krstić, Slobodan
Radmanović, Nikola
Jovanović, Sanja
Stefanović, Branislav
Influence of Syrgical Trauma on Nitric Oxide and Nitrotyrosine Serum Levels in Patients Undergoing Laparoscopic Or Conventional Cholecystectomy
title Influence of Syrgical Trauma on Nitric Oxide and Nitrotyrosine Serum Levels in Patients Undergoing Laparoscopic Or Conventional Cholecystectomy
title_full Influence of Syrgical Trauma on Nitric Oxide and Nitrotyrosine Serum Levels in Patients Undergoing Laparoscopic Or Conventional Cholecystectomy
title_fullStr Influence of Syrgical Trauma on Nitric Oxide and Nitrotyrosine Serum Levels in Patients Undergoing Laparoscopic Or Conventional Cholecystectomy
title_full_unstemmed Influence of Syrgical Trauma on Nitric Oxide and Nitrotyrosine Serum Levels in Patients Undergoing Laparoscopic Or Conventional Cholecystectomy
title_short Influence of Syrgical Trauma on Nitric Oxide and Nitrotyrosine Serum Levels in Patients Undergoing Laparoscopic Or Conventional Cholecystectomy
title_sort influence of syrgical trauma on nitric oxide and nitrotyrosine serum levels in patients undergoing laparoscopic or conventional cholecystectomy
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471650/
https://www.ncbi.nlm.nih.gov/pubmed/28680361
http://dx.doi.org/10.1515/jomb-2017-0004
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