Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha

BACKGROUND: Volatile anesthetics increase levels of the neurotransmitter nitric oxide (NO) and the secondary messenger molecule cyclic guanosine monophosphate (cGMP) in the brain. NO activates the enzyme guanylyl cyclase (GC) to produce cGMP. We hypothesized that the NO-GC-cGMP pathway contributes t...

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Detalles Bibliográficos
Autores principales: Nagasaka, Yasuko, Wepler, Martin, Thoonen, Robrecht, Sips, Patrick Y., Allen, Kaitlin, Graw, Jan A., Yao, Vincent, Burns, Sara M., Muenster, Stefan, Brouckaert, Peter, Miller, Keith, Solt, Ken, Buys, Emmanuel S., Ichinose, Fumito, Zapol, Warren M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471676/
https://www.ncbi.nlm.nih.gov/pubmed/28615047
http://dx.doi.org/10.1186/s12871-017-0368-5

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