Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review

Pemetrexed is a multitargeted antifolate that has demonstrated antitumor activity in non-small cell lung cancer. A 70-year-old male presented with a stage IV non-small cell lung cancer. The patient was treated with pemetrexed as third-line chemotherapy. However, a pneumothorax occurred 16 days after...

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Autores principales: Nakahara, Yoshiro, Mikura, Shinichiro, Nagamata, Makoto, Fukui, Tomoya, Sasaki, Jiichiro, Masuda, Noriyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471783/
https://www.ncbi.nlm.nih.gov/pubmed/28626401
http://dx.doi.org/10.1159/000471479
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author Nakahara, Yoshiro
Mikura, Shinichiro
Nagamata, Makoto
Fukui, Tomoya
Sasaki, Jiichiro
Masuda, Noriyuki
author_facet Nakahara, Yoshiro
Mikura, Shinichiro
Nagamata, Makoto
Fukui, Tomoya
Sasaki, Jiichiro
Masuda, Noriyuki
author_sort Nakahara, Yoshiro
collection PubMed
description Pemetrexed is a multitargeted antifolate that has demonstrated antitumor activity in non-small cell lung cancer. A 70-year-old male presented with a stage IV non-small cell lung cancer. The patient was treated with pemetrexed as third-line chemotherapy. However, a pneumothorax occurred 16 days after the administration of the second cycle of pemetrexed. The pneumothorax was slight and the patient was observed without undergoing any additional treatment. Twenty-four days after its initial occurrence, the pneumothorax had improved. This is the first case of pneumothorax that has been observed during pemetrexed treatment. Pneumothorax during chemotherapy is rare; however, it is a life-threatening complication and should not be overlooked.
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spelling pubmed-54717832017-06-16 Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review Nakahara, Yoshiro Mikura, Shinichiro Nagamata, Makoto Fukui, Tomoya Sasaki, Jiichiro Masuda, Noriyuki Case Rep Oncol Case Report Pemetrexed is a multitargeted antifolate that has demonstrated antitumor activity in non-small cell lung cancer. A 70-year-old male presented with a stage IV non-small cell lung cancer. The patient was treated with pemetrexed as third-line chemotherapy. However, a pneumothorax occurred 16 days after the administration of the second cycle of pemetrexed. The pneumothorax was slight and the patient was observed without undergoing any additional treatment. Twenty-four days after its initial occurrence, the pneumothorax had improved. This is the first case of pneumothorax that has been observed during pemetrexed treatment. Pneumothorax during chemotherapy is rare; however, it is a life-threatening complication and should not be overlooked. S. Karger AG 2017-05-09 /pmc/articles/PMC5471783/ /pubmed/28626401 http://dx.doi.org/10.1159/000471479 Text en Copyright © 2017 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Nakahara, Yoshiro
Mikura, Shinichiro
Nagamata, Makoto
Fukui, Tomoya
Sasaki, Jiichiro
Masuda, Noriyuki
Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review
title Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review
title_full Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review
title_fullStr Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review
title_full_unstemmed Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review
title_short Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review
title_sort pneumothorax during pemetrexed treatment in a patient with non-small cell lung cancer: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471783/
https://www.ncbi.nlm.nih.gov/pubmed/28626401
http://dx.doi.org/10.1159/000471479
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