Dissecting the human microbiome with single-cell genomics

Recent advances in genome sequencing of single microbial cells enable the assignment of functional roles to members of the human microbiome that cannot currently be cultured. This approach can reveal the genomic basis of phenotypic variation between closely related strains and can be applied to the...

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Detalles Bibliográficos
Autores principales: Tolonen, Andrew C., Xavier, Ramnik J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471897/
https://www.ncbi.nlm.nih.gov/pubmed/28615076
http://dx.doi.org/10.1186/s13073-017-0448-7
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author Tolonen, Andrew C.
Xavier, Ramnik J.
author_facet Tolonen, Andrew C.
Xavier, Ramnik J.
author_sort Tolonen, Andrew C.
collection PubMed
description Recent advances in genome sequencing of single microbial cells enable the assignment of functional roles to members of the human microbiome that cannot currently be cultured. This approach can reveal the genomic basis of phenotypic variation between closely related strains and can be applied to the targeted study of immunogenic bacteria in disease.
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spelling pubmed-54718972017-06-19 Dissecting the human microbiome with single-cell genomics Tolonen, Andrew C. Xavier, Ramnik J. Genome Med Comment Recent advances in genome sequencing of single microbial cells enable the assignment of functional roles to members of the human microbiome that cannot currently be cultured. This approach can reveal the genomic basis of phenotypic variation between closely related strains and can be applied to the targeted study of immunogenic bacteria in disease. BioMed Central 2017-06-14 /pmc/articles/PMC5471897/ /pubmed/28615076 http://dx.doi.org/10.1186/s13073-017-0448-7 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Tolonen, Andrew C.
Xavier, Ramnik J.
Dissecting the human microbiome with single-cell genomics
title Dissecting the human microbiome with single-cell genomics
title_full Dissecting the human microbiome with single-cell genomics
title_fullStr Dissecting the human microbiome with single-cell genomics
title_full_unstemmed Dissecting the human microbiome with single-cell genomics
title_short Dissecting the human microbiome with single-cell genomics
title_sort dissecting the human microbiome with single-cell genomics
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471897/
https://www.ncbi.nlm.nih.gov/pubmed/28615076
http://dx.doi.org/10.1186/s13073-017-0448-7
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