A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging

Aggregation, red-NIR emission and light-up upon nucleic acid G-quadruplex binding have been investigated for a prototype core-extended naphthalene diimide, which is capable of fast cellular entry and nucleolar localization. Both high-level colocalization with an anti-G-quadruplex antibody and nucleo...

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Autores principales: Doria, F., Nadai, M., Zuffo, M., Perrone, R., Freccero, M., Richter, S. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471928/
https://www.ncbi.nlm.nih.gov/pubmed/28149992
http://dx.doi.org/10.1039/c6cc08492c
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author Doria, F.
Nadai, M.
Zuffo, M.
Perrone, R.
Freccero, M.
Richter, S. N.
author_facet Doria, F.
Nadai, M.
Zuffo, M.
Perrone, R.
Freccero, M.
Richter, S. N.
author_sort Doria, F.
collection PubMed
description Aggregation, red-NIR emission and light-up upon nucleic acid G-quadruplex binding have been investigated for a prototype core-extended naphthalene diimide, which is capable of fast cellular entry and nucleolar localization. Both high-level colocalization with an anti-G-quadruplex antibody and nucleolin displacement reveal that the compound targets and thus makes visible nuclear DNA G-quadruplexes.
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spelling pubmed-54719282017-06-28 A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging Doria, F. Nadai, M. Zuffo, M. Perrone, R. Freccero, M. Richter, S. N. Chem Commun (Camb) Chemistry Aggregation, red-NIR emission and light-up upon nucleic acid G-quadruplex binding have been investigated for a prototype core-extended naphthalene diimide, which is capable of fast cellular entry and nucleolar localization. Both high-level colocalization with an anti-G-quadruplex antibody and nucleolin displacement reveal that the compound targets and thus makes visible nuclear DNA G-quadruplexes. Royal Society of Chemistry 2017-02-18 2017-01-23 /pmc/articles/PMC5471928/ /pubmed/28149992 http://dx.doi.org/10.1039/c6cc08492c Text en This journal is © The Royal Society of Chemistry 2017 https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Doria, F.
Nadai, M.
Zuffo, M.
Perrone, R.
Freccero, M.
Richter, S. N.
A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging
title A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging
title_full A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging
title_fullStr A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging
title_full_unstemmed A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging
title_short A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging
title_sort red-nir fluorescent dye detecting nuclear dna g-quadruplexes: in vitro analysis and cell imaging
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471928/
https://www.ncbi.nlm.nih.gov/pubmed/28149992
http://dx.doi.org/10.1039/c6cc08492c
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