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Spaser as a biological probe
Understanding cell biology greatly benefits from the development of advanced diagnostic probes. Here we introduce a 22-nm spaser (plasmonic nanolaser) with the ability to serve as a super-bright, water-soluble, biocompatible probe capable of generating stimulated emission directly inside living cell...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472166/ https://www.ncbi.nlm.nih.gov/pubmed/28593987 http://dx.doi.org/10.1038/ncomms15528 |
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author | Galanzha, Ekaterina I. Weingold, Robert Nedosekin, Dmitry A. Sarimollaoglu, Mustafa Nolan, Jacqueline Harrington, Walter Kuchyanov, Alexander S. Parkhomenko, Roman G. Watanabe, Fumiya Nima, Zeid Biris, Alexandru S. Plekhanov, Alexander I. Stockman, Mark I. Zharov, Vladimir P. |
author_facet | Galanzha, Ekaterina I. Weingold, Robert Nedosekin, Dmitry A. Sarimollaoglu, Mustafa Nolan, Jacqueline Harrington, Walter Kuchyanov, Alexander S. Parkhomenko, Roman G. Watanabe, Fumiya Nima, Zeid Biris, Alexandru S. Plekhanov, Alexander I. Stockman, Mark I. Zharov, Vladimir P. |
author_sort | Galanzha, Ekaterina I. |
collection | PubMed |
description | Understanding cell biology greatly benefits from the development of advanced diagnostic probes. Here we introduce a 22-nm spaser (plasmonic nanolaser) with the ability to serve as a super-bright, water-soluble, biocompatible probe capable of generating stimulated emission directly inside living cells and animal tissues. We have demonstrated a lasing regime associated with the formation of a dynamic vapour nanobubble around the spaser that leads to giant spasing with emission intensity and spectral width >100 times brighter and 30-fold narrower, respectively, than for quantum dots. The absorption losses in the spaser enhance its multifunctionality, allowing for nanobubble-amplified photothermal and photoacoustic imaging and therapy. Furthermore, the silica spaser surface has been covalently functionalized with folic acid for molecular targeting of cancer cells. All these properties make a nanobubble spaser a promising multimodal, super-contrast, ultrafast cellular probe with a single-pulse nanosecond excitation for a variety of in vitro and in vivo biomedical applications. |
format | Online Article Text |
id | pubmed-5472166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-54721662017-06-28 Spaser as a biological probe Galanzha, Ekaterina I. Weingold, Robert Nedosekin, Dmitry A. Sarimollaoglu, Mustafa Nolan, Jacqueline Harrington, Walter Kuchyanov, Alexander S. Parkhomenko, Roman G. Watanabe, Fumiya Nima, Zeid Biris, Alexandru S. Plekhanov, Alexander I. Stockman, Mark I. Zharov, Vladimir P. Nat Commun Article Understanding cell biology greatly benefits from the development of advanced diagnostic probes. Here we introduce a 22-nm spaser (plasmonic nanolaser) with the ability to serve as a super-bright, water-soluble, biocompatible probe capable of generating stimulated emission directly inside living cells and animal tissues. We have demonstrated a lasing regime associated with the formation of a dynamic vapour nanobubble around the spaser that leads to giant spasing with emission intensity and spectral width >100 times brighter and 30-fold narrower, respectively, than for quantum dots. The absorption losses in the spaser enhance its multifunctionality, allowing for nanobubble-amplified photothermal and photoacoustic imaging and therapy. Furthermore, the silica spaser surface has been covalently functionalized with folic acid for molecular targeting of cancer cells. All these properties make a nanobubble spaser a promising multimodal, super-contrast, ultrafast cellular probe with a single-pulse nanosecond excitation for a variety of in vitro and in vivo biomedical applications. Nature Publishing Group 2017-06-08 /pmc/articles/PMC5472166/ /pubmed/28593987 http://dx.doi.org/10.1038/ncomms15528 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Galanzha, Ekaterina I. Weingold, Robert Nedosekin, Dmitry A. Sarimollaoglu, Mustafa Nolan, Jacqueline Harrington, Walter Kuchyanov, Alexander S. Parkhomenko, Roman G. Watanabe, Fumiya Nima, Zeid Biris, Alexandru S. Plekhanov, Alexander I. Stockman, Mark I. Zharov, Vladimir P. Spaser as a biological probe |
title | Spaser as a biological probe |
title_full | Spaser as a biological probe |
title_fullStr | Spaser as a biological probe |
title_full_unstemmed | Spaser as a biological probe |
title_short | Spaser as a biological probe |
title_sort | spaser as a biological probe |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472166/ https://www.ncbi.nlm.nih.gov/pubmed/28593987 http://dx.doi.org/10.1038/ncomms15528 |
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