Loss of Asxl2 leads to myeloid malignancies in mice

ASXL2 is frequently mutated in acute myeloid leukaemia patients with t(8;21). However, the roles of ASXL2 in normal haematopoiesis and the pathogenesis of myeloid malignancies remain unknown. Here we show that deletion of Asxl2 in mice leads to the development of myelodysplastic syndrome (MDS)-like...

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Detalles Bibliográficos
Autores principales: Li, Jianping, He, Fuhong, Zhang, Peng, Chen, Shi, Shi, Hui, Sun, Yanling, Guo, Ying, Yang, Hui, Man, Na, Greenblatt, Sarah, Li, Zhaomin, Guo, Zhengyu, Zhou, Yuan, Wang, Lan, Morey, Lluis, Williams, Sion, Chen, Xi, Wang, Qun-Tian, Nimer, Stephen D., Yu, Peng, Wang, Qian-Fei, Xu, Mingjiang, Yang, Feng-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472177/
https://www.ncbi.nlm.nih.gov/pubmed/28593990
http://dx.doi.org/10.1038/ncomms15456

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