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Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells

Pyruvate dehydrogenase kinase 1 (PDK1) is overexpressed in ovarian cancer and thus is a promising anticancer therapeutic target. Our previous work suggests that coumarin compounds are potential inhibitors of PDKs. In this study, we used the ovarian cancer cell line SKOV3 as the model system and exam...

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Detalles Bibliográficos
Autores principales:	Zhang, Wenjia, Su, Jing, Xu, Huadan, Yu, Shanshan, Liu, Yanan, Zhang, Yong, Sun, Liankun, Yue, Ying, Zhou, Xiaoli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472302/ https://www.ncbi.nlm.nih.gov/pubmed/28617852 http://dx.doi.org/10.1371/journal.pone.0179672

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