Cargando…

Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole

G-quadruplex (G4) is a higher-order nucleic acid structure that is formed by guanine-rich sequences. G4 stabilization by small-molecule compounds called G4 ligands often causes cytotoxicity, although the potential medicinal impact of this effect has not been fully established. Here we demonstrate th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakamura, Takahiro, Okabe, Sachiko, Yoshida, Haruka, Iida, Keisuke, Ma, Yue, Sasaki, Shogo, Yamori, Takao, Shin-ya, Kazuo, Nakano, Ichiro, Nagasawa, Kazuo, Seimiya, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472576/ https://www.ncbi.nlm.nih.gov/pubmed/28620243 http://dx.doi.org/10.1038/s41598-017-03785-8

Ejemplares similares

Evaluation of the Interaction between Long Telomeric DNA and Macrocyclic Hexaoxazole (6OTD) Dimer of a G-quadruplex Ligand
por: Iida, Keisuke, et al.
Publicado: (2013)

Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chains
por: Ma, Yue, et al.
Publicado: (2019)

Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties
por: Iida, Keisuke, et al.
Publicado: (2010)

Linear consecutive hexaoxazoles as G4 ligands inducing chair-type anti-parallel topology of a telomeric G-quadruplex
por: Sasaki, Shogo, et al.
Publicado: (2020)

Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA
por: Barbieri, Christopher M., et al.
Publicado: (2007)

A single molecule study of a fluorescently labeled telomestatin derivative and G-quadruplex interactions
por: Maleki, Parastoo, et al.
Publicado: (2017)

Identification of G-quadruplex clusters by high-throughput sequencing of whole-genome amplified products with a G-quadruplex ligand
por: Yoshida, Wataru, et al.
Publicado: (2018)

Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities
por: Masai, Hisao, et al.
Publicado: (2019)

Identification of G-quadruplex structures that possess transcriptional regulating functions in the Dele and Cdc6 CpG islands
por: Bay, Daniyah H., et al.
Publicado: (2017)

Detection of CpG Methylation in G-Quadruplex Forming Sequences Using G-Quadruplex Ligands
por: Hasegawa, Hijiri, et al.
Publicado: (2021)

G-Quadruplexes as Potential Therapeutic Targets for Embryonal Tumors
por: Shalaby, Tarek, et al.
Publicado: (2013)

G‐quadruplex‐forming nucleic acids interact with splicing factor 3B subunit 2 and suppress innate immune gene expression
por: Matsumoto, Kyoko, et al.
Publicado: (2021)

Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles
por: Yu, Xufen, et al.
Publicado: (2013)

Impact of Small Molecules on Intermolecular G-Quadruplex Formation
por: Gyawali, Prabesh, et al.
Publicado: (2019)

Using Macrocyclic G‐Quadruplex Ligands to Decipher the Interactions Between Small Molecules and G‐Quadruplex DNA
por: Andréasson, Måns, et al.
Publicado: (2022)

A G-quadruplex structure at the 5′ end of the H19 coding region regulates H19 transcription
por: Fukuhara, Mitsuko, et al.
Publicado: (2017)

Macrocyclization of bis-indole quinolines for selective stabilization of G-quadruplex DNA structures
por: Das, Rabindra Nath, et al.
Publicado: (2020)

Quantifying the impact of small molecule ligands on G-quadruplex stability against Bloom helicase
por: Maleki, Parastoo, et al.
Publicado: (2019)

Biphenarenes, Versatile Synthetic Macrocycles for Supramolecular Chemistry
por: Zhang, Wenjie, et al.
Publicado: (2023)

CPL on/off control of an assembled system by water soluble macrocyclic chiral sources with planar chirality
por: Fa, Shixin, et al.
Publicado: (2022)

Development of a novel light-up probe for detection of G-quadruplexes in stress granules
por: Iida, Keisuke, et al.
Publicado: (2022)

Inhibition of proliferation and induction of differentiation of glioma cells with Datura stramonium agglutinin
por: Sasaki, T, et al.
Publicado: (2002)

Synthetic approaches to metal-coordination-directed macrocyclic complexes
por: Fang, Qingqing, et al.
Publicado: (2022)

Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor
por: Adachi, Kanna, et al.
Publicado: (2019)

Potential Effects of Soy Isoflavones on the Prevention of Metabolic Syndrome
por: Yamagata, Kazuo, et al.
Publicado: (2021)

Identification of a Novel Compound That Suppresses Breast Cancer Invasiveness by Inhibiting Transforming Growth Factor-β Signaling via Estrogen Receptor α
por: Goto, Natsuka, et al.
Publicado: (2014)

“One Ring to Bind Them All”—Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition
por: Monchaud, David, et al.
Publicado: (2010)

Macrocyclic Pyridyl Polyoxazoles: Structure-Activity Studies of the Aminoalkyl Side-Chain on G-Quadruplex Stabilization and Cytotoxic Activity
por: Blankson, Gifty, et al.
Publicado: (2013)

Telomeric repeat-containing RNA/G-quadruplex-forming sequences cause genome-wide alteration of gene expression in human cancer cells in vivo
por: Hirashima, Kyotaro, et al.
Publicado: (2015)

The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells
por: Temime-Smaali, Nassima, et al.
Publicado: (2009)

Cation Involvement in Telomestatin Binding to G-Quadruplex DNA
por: Rosu, Frédéric, et al.
Publicado: (2010)

Fertility Inhibitors Macrocyclic Complexes of Bivalent Manganese: Synthetic, Spectroscopic and Medicinal Approach
por: Singh, R. V., et al.
Publicado: (2003)

Synthetic fermentation of β-peptide macrocycles by thiadiazole-forming ring-closing reactions
por: Hubert, Jonathan G., et al.
Publicado: (2018)

Synthetic Strategy and Anti-Tumor Activities of Macrocyclic Scaffolds Based on 4-Hydroxyproline
por: Cao, Guorui, et al.
Publicado: (2016)

Synthetic Studies on Amphidinolide F: Exploration of Macrocycle Construction by Intramolecular Stille Coupling
por: Decultot, Ludovic, et al.
Publicado: (2022)

Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells
por: Fujiwara, Chiaki, et al.
Publicado: (2018)

“One Ring to Bind Them All”—Part II: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-Type Macrocycles
por: Granzhan, Anton, et al.
Publicado: (2010)

2-(4-Hydroxy-3-methoxyphenyl)-benzothiazole suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP
por: Hiyoshi, Hiromi, et al.
Publicado: (2014)

Post-synthetic modification of a macrocyclic receptor via regioselective imidazolium ring-opening
por: Shang, Jia, et al.
Publicado: (2016)

Synthetic antibacterial discovery of symbah-1, a macrocyclic β-hairpin peptide antibiotic
por: Randall, Justin R., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_s590pl0tgpqf5ite7rikkrum94