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EZH2-mediated epigenetic silencing of TIMP2 promotes ovarian cancer migration and invasion

Enhancer of zeste homolog 2 (EZH2) is often increased in malignant tumors and is involved in metastasis. EZH2 silences gene expression by tri-methylating the lysine 27 residue of histone H3 (H3K27me3). However, the mechanism underlying EZH2 promotion of ovarian cancer metastasis remains elusive. Her...

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Detalles Bibliográficos
Autores principales:	Yi, Xiaoqing, Guo, Jianfeng, Guo, Jing, Sun, Si, Yang, Ping, Wang, Junjie, Li, Yuan, Xie, Lisha, Cai, Jing, Wang, Zehua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472630/ https://www.ncbi.nlm.nih.gov/pubmed/28620234 http://dx.doi.org/10.1038/s41598-017-03362-z

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