Cargando…

Structural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid Quercetin

Small molecule ligands that could stabilize G-quadruplex structure formed at the promoter region of human c-myc oncogene will regulate its expression in cancer cells. Flavonoids, a group of naturally available small molecule, have been known for their various promising effects on human health. In pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tawani, Arpita, Mishra, Subodh Kumar, Kumar, Amit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472631/ https://www.ncbi.nlm.nih.gov/pubmed/28620169 http://dx.doi.org/10.1038/s41598-017-03906-3

Ejemplares similares

G4IPDB: A database for G-quadruplex structure forming nucleic acid interacting proteins
por: Mishra, Subodh Kumar, et al.
Publicado: (2016)

Structural Insight into the interaction of Flavonoids with Human Telomeric Sequence
por: Tawani, Arpita, et al.
Publicado: (2015)

Evidences for Piperine inhibiting cancer by targeting human G-quadruplex DNA sequences
por: Tawani, Arpita, et al.
Publicado: (2016)

Characterization of highly conserved G-quadruplex motifs as potential drug targets in Streptococcus pneumoniae
por: Mishra, Subodh Kumar, et al.
Publicado: (2019)

Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes
por: Dickerhoff, Jonathan, et al.
Publicado: (2021)

Structural Insights Reveal the Dynamics of the Repeating r(CAG) Transcript Found in Huntington’s Disease (HD) and Spinocerebellar Ataxias (SCAs)
por: Tawani, Arpita, et al.
Publicado: (2015)

Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex
por: Calabrese, David R., et al.
Publicado: (2018)

SMMDB: a web-accessible database for small molecule modulators and their targets involved in neurological diseases
por: Mishra, Subodh Kumar, et al.
Publicado: (2018)

Quantitative Formation of Monomeric G‐Quadruplex DNA from Multimeric Structures of c‐Myc Promoter Sequence
por: Rauser, Valerie, et al.
Publicado: (2020)

Identification and characterization of two conserved G-quadruplex forming motifs in the Nipah virus genome and their interaction with G-quadruplex specific ligands
por: Majee, Prativa, et al.
Publicado: (2020)

Significant structural change in human c-Myc promoter G-quadruplex upon peptide binding in potassium
por: Kundu, Nikita, et al.
Publicado: (2022)

A Thermodynamic Perspective on Potential G‐Quadruplex Structures as Silencer Elements in the MYC Promoter
por: Jana, Jagannath, et al.
Publicado: (2020)

Structural insights and shedding light on preferential interactions of dietary flavonoids with G-quadruplex DNA structures: A new horizon
por: Bag, Sagar, et al.
Publicado: (2023)

Nucleic acid clamp-mediated recognition and stabilization of the physiologically relevant MYC promoter G-quadruplex
por: Hao, Taisen, et al.
Publicado: (2016)

Solution Structure of a MYC Promoter G-Quadruplex with 1:6:1 Loop Length
por: Dickerhoff, Jonathan, et al.
Publicado: (2019)

Conserved G-Quadruplex Motifs in Gene Promoter Region Reveals a Novel Therapeutic Approach to Target Multi-Drug Resistance Klebsiella pneumoniae
por: Shankar, Uma, et al.
Publicado: (2020)

Structures of 1:1 and 2:1 complexes of BMVC and MYC promoter G-quadruplex reveal a mechanism of ligand conformation adjustment for G4-recognition
por: Liu, Wenting, et al.
Publicado: (2019)

Selective recognition of c-MYC Pu22 G-quadruplex by a fluorescent probe
por: Zhai, Qianqian, et al.
Publicado: (2019)

G-quadruplex stabilization in the ions and maltose transporters gene inhibit Salmonella enterica growth and virulence
por: Jain, Neha, et al.
Publicado: (2020)

G-Quadruplexes in c-MYC Promoter as Targets for Cancer Therapy
por: Bahls, Bárbara, et al.
Publicado: (2023)

Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths
por: Ranjan, Nihar, et al.
Publicado: (2013)

Ruthenation of Non‐stacked Guanines in DNA G‐Quadruplex Structures: Enhancement of c‐MYC Expression
por: Rodríguez, Jéssica, et al.
Publicado: (2016)

G-quadruplex structure of an anti-proliferative DNA sequence
por: Do, Ngoc Quang, et al.
Publicado: (2017)

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K(+): insights into loop interactions of the parallel G-quadruplexes
por: Agrawal, Prashansa, et al.
Publicado: (2013)

Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences
por: Monsen, Robert C, et al.
Publicado: (2022)

Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K(+) solution: insights into the interconversion of human telomeric G-quadruplex structures
por: Zhang, Zhenjiang, et al.
Publicado: (2010)

c-MYC promoter G-quadruplex formed at the 5′-end of NHE III(1) element: insights into biological relevance and parallel-stranded G-quadruplex stability
por: Mathad, Raveendra I., et al.
Publicado: (2011)

Wild-type p53 binds to MYC promoter G-quadruplex
por: Petr, Marek, et al.
Publicado: (2016)

G-Quadruplex-Forming DNA Aptamers Inhibit the DNA-Binding Function of HupB and Mycobacterium tuberculosis Entry into Host Cells
por: Kalra, Priya, et al.
Publicado: (2018)

Insights into telomeric G-quadruplex DNA recognition by HMGB1 protein
por: Amato, Jussara, et al.
Publicado: (2019)

Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene
por: Stump, Sascha, et al.
Publicado: (2018)

Targeted Downregulation of MYC through G-quadruplex Stabilization by DNAi
por: Psaras, Alexandra Maria, et al.
Publicado: (2021)

Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation
por: Keller, Josephine Geertsen, et al.
Publicado: (2022)

Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
por: Kashyap, Dharambir, et al.
Publicado: (2019)

Parallel G-quadruplex recognition by neomycin
por: Ranjan, Nihar, et al.
Publicado: (2023)

Stability and kinetics of G-quadruplex structures
por: Lane, Andrew N., et al.
Publicado: (2008)

Relevance of G-quadruplex structures to pharmacogenetics
por: Cree, Simone L., et al.
Publicado: (2014)

The Structure and Function of DNA G-Quadruplexes
por: Spiegel, Jochen, et al.
Publicado: (2020)

Structure and Function of Multimeric G-Quadruplexes
por: Kolesnikova, Sofia, et al.
Publicado: (2019)

Characterization of G-Quadruplex Motifs in espB, espK, and cyp51 Genes of Mycobacterium tuberculosis as Potential Drug Targets
por: Mishra, Subodh Kumar, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_909hpomm13lvmrvq50a5e0rn2n