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Biological Functions of the Secretome of Neisseria meningitidis

Neisseria meningitidis is a Gram-negative bacterial pathogen that normally resides as a commensal in the human nasopharynx but occasionally causes disease with high mortality and morbidity. To interact with its environment, it transports many proteins across the outer membrane to the bacterial cell...

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Autores principales: Tommassen, Jan, Arenas, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472700/
https://www.ncbi.nlm.nih.gov/pubmed/28670572
http://dx.doi.org/10.3389/fcimb.2017.00256
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author Tommassen, Jan
Arenas, Jesús
author_facet Tommassen, Jan
Arenas, Jesús
author_sort Tommassen, Jan
collection PubMed
description Neisseria meningitidis is a Gram-negative bacterial pathogen that normally resides as a commensal in the human nasopharynx but occasionally causes disease with high mortality and morbidity. To interact with its environment, it transports many proteins across the outer membrane to the bacterial cell surface and into the extracellular medium for which it deploys the common and well-characterized autotransporter, two-partner and type I secretion mechanisms, as well as a recently discovered pathway for the surface exposure of lipoproteins. The surface-exposed and secreted proteins serve roles in host-pathogen interactions, including adhesion to host cells and extracellular matrix proteins, evasion of nutritional immunity imposed by iron-binding proteins of the host, prevention of complement activation, neutralization of antimicrobial peptides, degradation of immunoglobulins, and permeabilization of epithelial layers. Furthermore, they have roles in interbacterial interactions, including the formation and dispersal of biofilms and the suppression of the growth of bacteria competing for the same niche. Here, we will review the protein secretion systems of N. meningitidis and focus on the functions of the secreted proteins.
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spelling pubmed-54727002017-06-30 Biological Functions of the Secretome of Neisseria meningitidis Tommassen, Jan Arenas, Jesús Front Cell Infect Microbiol Microbiology Neisseria meningitidis is a Gram-negative bacterial pathogen that normally resides as a commensal in the human nasopharynx but occasionally causes disease with high mortality and morbidity. To interact with its environment, it transports many proteins across the outer membrane to the bacterial cell surface and into the extracellular medium for which it deploys the common and well-characterized autotransporter, two-partner and type I secretion mechanisms, as well as a recently discovered pathway for the surface exposure of lipoproteins. The surface-exposed and secreted proteins serve roles in host-pathogen interactions, including adhesion to host cells and extracellular matrix proteins, evasion of nutritional immunity imposed by iron-binding proteins of the host, prevention of complement activation, neutralization of antimicrobial peptides, degradation of immunoglobulins, and permeabilization of epithelial layers. Furthermore, they have roles in interbacterial interactions, including the formation and dispersal of biofilms and the suppression of the growth of bacteria competing for the same niche. Here, we will review the protein secretion systems of N. meningitidis and focus on the functions of the secreted proteins. Frontiers Media S.A. 2017-06-16 /pmc/articles/PMC5472700/ /pubmed/28670572 http://dx.doi.org/10.3389/fcimb.2017.00256 Text en Copyright © 2017 Tommassen and Arenas. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Tommassen, Jan
Arenas, Jesús
Biological Functions of the Secretome of Neisseria meningitidis
title Biological Functions of the Secretome of Neisseria meningitidis
title_full Biological Functions of the Secretome of Neisseria meningitidis
title_fullStr Biological Functions of the Secretome of Neisseria meningitidis
title_full_unstemmed Biological Functions of the Secretome of Neisseria meningitidis
title_short Biological Functions of the Secretome of Neisseria meningitidis
title_sort biological functions of the secretome of neisseria meningitidis
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472700/
https://www.ncbi.nlm.nih.gov/pubmed/28670572
http://dx.doi.org/10.3389/fcimb.2017.00256
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