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Genome-wide association study identifies multiple risk loci for renal cell carcinoma
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-fou...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472706/ https://www.ncbi.nlm.nih.gov/pubmed/28598434 http://dx.doi.org/10.1038/ncomms15724 |
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| author | Scelo, Ghislaine Purdue, Mark P. Brown, Kevin M. Johansson, Mattias Wang, Zhaoming Eckel-Passow, Jeanette E. Ye, Yuanqing Hofmann, Jonathan N. Choi, Jiyeon Foll, Matthieu Gaborieau, Valerie Machiela, Mitchell J. Colli, Leandro M. Li, Peng Sampson, Joshua N. Abedi-Ardekani, Behnoush Besse, Celine Blanche, Helene Boland, Anne Burdette, Laurie Chabrier, Amelie Durand, Geoffroy Le Calvez-Kelm, Florence Prokhortchouk, Egor Robinot, Nivonirina Skryabin, Konstantin G. Wozniak, Magdalena B. Yeager, Meredith Basta-Jovanovic, Gordana Dzamic, Zoran Foretova, Lenka Holcatova, Ivana Janout, Vladimir Mates, Dana Mukeriya, Anush Rascu, Stefan Zaridze, David Bencko, Vladimir Cybulski, Cezary Fabianova, Eleonora Jinga, Viorel Lissowska, Jolanta Lubinski, Jan Navratilova, Marie Rudnai, Peter Szeszenia-Dabrowska, Neonila Benhamou, Simone Cancel-Tassin, Geraldine Cussenot, Olivier Baglietto, Laura Boeing, Heiner Khaw, Kay-Tee Weiderpass, Elisabete Ljungberg, Borje Sitaram, Raviprakash T. Bruinsma, Fiona Jordan, Susan J. Severi, Gianluca Winship, Ingrid Hveem, Kristian Vatten, Lars J. Fletcher, Tony Koppova, Kvetoslava Larsson, Susanna C. Wolk, Alicja Banks, Rosamonde E. Selby, Peter J. Easton, Douglas F. Pharoah, Paul Andreotti, Gabriella Freeman, Laura E. Beane Koutros, Stella Albanes, Demetrius Männistö, Satu Weinstein, Stephanie Clark, Peter E. Edwards, Todd L. Lipworth, Loren Gapstur, Susan M. Stevens, Victoria L. Carol, Hallie Freedman, Matthew L. Pomerantz, Mark M. Cho, Eunyoung Kraft, Peter Preston, Mark A. Wilson, Kathryn M. Michael Gaziano, J. Sesso, Howard D. Black, Amanda Freedman, Neal D. Huang, Wen-Yi Anema, John G. Kahnoski, Richard J. Lane, Brian R. Noyes, Sabrina L. Petillo, David Teh, Bin Tean Peters, Ulrike White, Emily Anderson, Garnet L. Johnson, Lisa Luo, Juhua Buring, Julie Lee, I-Min Chow, Wong-Ho Moore, Lee E. Wood, Christopher Eisen, Timothy Henrion, Marc Larkin, James Barman, Poulami Leibovich, Bradley C. Choueiri, Toni K. Mark Lathrop, G. Rothman, Nathaniel Deleuze, Jean-Francois McKay, James D. Parker, Alexander S. Wu, Xifeng Houlston, Richard S. Brennan, Paul Chanock, Stephen J. |
| author_facet | Scelo, Ghislaine Purdue, Mark P. Brown, Kevin M. Johansson, Mattias Wang, Zhaoming Eckel-Passow, Jeanette E. Ye, Yuanqing Hofmann, Jonathan N. Choi, Jiyeon Foll, Matthieu Gaborieau, Valerie Machiela, Mitchell J. Colli, Leandro M. Li, Peng Sampson, Joshua N. Abedi-Ardekani, Behnoush Besse, Celine Blanche, Helene Boland, Anne Burdette, Laurie Chabrier, Amelie Durand, Geoffroy Le Calvez-Kelm, Florence Prokhortchouk, Egor Robinot, Nivonirina Skryabin, Konstantin G. Wozniak, Magdalena B. Yeager, Meredith Basta-Jovanovic, Gordana Dzamic, Zoran Foretova, Lenka Holcatova, Ivana Janout, Vladimir Mates, Dana Mukeriya, Anush Rascu, Stefan Zaridze, David Bencko, Vladimir Cybulski, Cezary Fabianova, Eleonora Jinga, Viorel Lissowska, Jolanta Lubinski, Jan Navratilova, Marie Rudnai, Peter Szeszenia-Dabrowska, Neonila Benhamou, Simone Cancel-Tassin, Geraldine Cussenot, Olivier Baglietto, Laura Boeing, Heiner Khaw, Kay-Tee Weiderpass, Elisabete Ljungberg, Borje Sitaram, Raviprakash T. Bruinsma, Fiona Jordan, Susan J. Severi, Gianluca Winship, Ingrid Hveem, Kristian Vatten, Lars J. Fletcher, Tony Koppova, Kvetoslava Larsson, Susanna C. Wolk, Alicja Banks, Rosamonde E. Selby, Peter J. Easton, Douglas F. Pharoah, Paul Andreotti, Gabriella Freeman, Laura E. Beane Koutros, Stella Albanes, Demetrius Männistö, Satu Weinstein, Stephanie Clark, Peter E. Edwards, Todd L. Lipworth, Loren Gapstur, Susan M. Stevens, Victoria L. Carol, Hallie Freedman, Matthew L. Pomerantz, Mark M. Cho, Eunyoung Kraft, Peter Preston, Mark A. Wilson, Kathryn M. Michael Gaziano, J. Sesso, Howard D. Black, Amanda Freedman, Neal D. Huang, Wen-Yi Anema, John G. Kahnoski, Richard J. Lane, Brian R. Noyes, Sabrina L. Petillo, David Teh, Bin Tean Peters, Ulrike White, Emily Anderson, Garnet L. Johnson, Lisa Luo, Juhua Buring, Julie Lee, I-Min Chow, Wong-Ho Moore, Lee E. Wood, Christopher Eisen, Timothy Henrion, Marc Larkin, James Barman, Poulami Leibovich, Bradley C. Choueiri, Toni K. Mark Lathrop, G. Rothman, Nathaniel Deleuze, Jean-Francois McKay, James D. Parker, Alexander S. Wu, Xifeng Houlston, Richard S. Brennan, Paul Chanock, Stephen J. |
| author_sort | Scelo, Ghislaine |
| collection | PubMed |
| description | Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10(−10)), 3p22.1 (rs67311347, P=2.5 × 10(−8)), 3q26.2 (rs10936602, P=8.8 × 10(−9)), 8p21.3 (rs2241261, P=5.8 × 10(−9)), 10q24.33-q25.1 (rs11813268, P=3.9 × 10(−8)), 11q22.3 (rs74911261, P=2.1 × 10(−10)) and 14q24.2 (rs4903064, P=2.2 × 10(−24)). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility. |
| format | Online Article Text |
| id | pubmed-5472706 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-54727062017-06-28 Genome-wide association study identifies multiple risk loci for renal cell carcinoma Scelo, Ghislaine Purdue, Mark P. Brown, Kevin M. Johansson, Mattias Wang, Zhaoming Eckel-Passow, Jeanette E. Ye, Yuanqing Hofmann, Jonathan N. Choi, Jiyeon Foll, Matthieu Gaborieau, Valerie Machiela, Mitchell J. Colli, Leandro M. Li, Peng Sampson, Joshua N. Abedi-Ardekani, Behnoush Besse, Celine Blanche, Helene Boland, Anne Burdette, Laurie Chabrier, Amelie Durand, Geoffroy Le Calvez-Kelm, Florence Prokhortchouk, Egor Robinot, Nivonirina Skryabin, Konstantin G. Wozniak, Magdalena B. Yeager, Meredith Basta-Jovanovic, Gordana Dzamic, Zoran Foretova, Lenka Holcatova, Ivana Janout, Vladimir Mates, Dana Mukeriya, Anush Rascu, Stefan Zaridze, David Bencko, Vladimir Cybulski, Cezary Fabianova, Eleonora Jinga, Viorel Lissowska, Jolanta Lubinski, Jan Navratilova, Marie Rudnai, Peter Szeszenia-Dabrowska, Neonila Benhamou, Simone Cancel-Tassin, Geraldine Cussenot, Olivier Baglietto, Laura Boeing, Heiner Khaw, Kay-Tee Weiderpass, Elisabete Ljungberg, Borje Sitaram, Raviprakash T. Bruinsma, Fiona Jordan, Susan J. Severi, Gianluca Winship, Ingrid Hveem, Kristian Vatten, Lars J. Fletcher, Tony Koppova, Kvetoslava Larsson, Susanna C. Wolk, Alicja Banks, Rosamonde E. Selby, Peter J. Easton, Douglas F. Pharoah, Paul Andreotti, Gabriella Freeman, Laura E. Beane Koutros, Stella Albanes, Demetrius Männistö, Satu Weinstein, Stephanie Clark, Peter E. Edwards, Todd L. Lipworth, Loren Gapstur, Susan M. Stevens, Victoria L. Carol, Hallie Freedman, Matthew L. Pomerantz, Mark M. Cho, Eunyoung Kraft, Peter Preston, Mark A. Wilson, Kathryn M. Michael Gaziano, J. Sesso, Howard D. Black, Amanda Freedman, Neal D. Huang, Wen-Yi Anema, John G. Kahnoski, Richard J. Lane, Brian R. Noyes, Sabrina L. Petillo, David Teh, Bin Tean Peters, Ulrike White, Emily Anderson, Garnet L. Johnson, Lisa Luo, Juhua Buring, Julie Lee, I-Min Chow, Wong-Ho Moore, Lee E. Wood, Christopher Eisen, Timothy Henrion, Marc Larkin, James Barman, Poulami Leibovich, Bradley C. Choueiri, Toni K. Mark Lathrop, G. Rothman, Nathaniel Deleuze, Jean-Francois McKay, James D. Parker, Alexander S. Wu, Xifeng Houlston, Richard S. Brennan, Paul Chanock, Stephen J. Nat Commun Article Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10(−10)), 3p22.1 (rs67311347, P=2.5 × 10(−8)), 3q26.2 (rs10936602, P=8.8 × 10(−9)), 8p21.3 (rs2241261, P=5.8 × 10(−9)), 10q24.33-q25.1 (rs11813268, P=3.9 × 10(−8)), 11q22.3 (rs74911261, P=2.1 × 10(−10)) and 14q24.2 (rs4903064, P=2.2 × 10(−24)). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility. Nature Publishing Group 2017-06-09 /pmc/articles/PMC5472706/ /pubmed/28598434 http://dx.doi.org/10.1038/ncomms15724 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Scelo, Ghislaine Purdue, Mark P. Brown, Kevin M. Johansson, Mattias Wang, Zhaoming Eckel-Passow, Jeanette E. Ye, Yuanqing Hofmann, Jonathan N. Choi, Jiyeon Foll, Matthieu Gaborieau, Valerie Machiela, Mitchell J. Colli, Leandro M. Li, Peng Sampson, Joshua N. Abedi-Ardekani, Behnoush Besse, Celine Blanche, Helene Boland, Anne Burdette, Laurie Chabrier, Amelie Durand, Geoffroy Le Calvez-Kelm, Florence Prokhortchouk, Egor Robinot, Nivonirina Skryabin, Konstantin G. Wozniak, Magdalena B. Yeager, Meredith Basta-Jovanovic, Gordana Dzamic, Zoran Foretova, Lenka Holcatova, Ivana Janout, Vladimir Mates, Dana Mukeriya, Anush Rascu, Stefan Zaridze, David Bencko, Vladimir Cybulski, Cezary Fabianova, Eleonora Jinga, Viorel Lissowska, Jolanta Lubinski, Jan Navratilova, Marie Rudnai, Peter Szeszenia-Dabrowska, Neonila Benhamou, Simone Cancel-Tassin, Geraldine Cussenot, Olivier Baglietto, Laura Boeing, Heiner Khaw, Kay-Tee Weiderpass, Elisabete Ljungberg, Borje Sitaram, Raviprakash T. Bruinsma, Fiona Jordan, Susan J. Severi, Gianluca Winship, Ingrid Hveem, Kristian Vatten, Lars J. Fletcher, Tony Koppova, Kvetoslava Larsson, Susanna C. Wolk, Alicja Banks, Rosamonde E. Selby, Peter J. Easton, Douglas F. Pharoah, Paul Andreotti, Gabriella Freeman, Laura E. Beane Koutros, Stella Albanes, Demetrius Männistö, Satu Weinstein, Stephanie Clark, Peter E. Edwards, Todd L. Lipworth, Loren Gapstur, Susan M. Stevens, Victoria L. Carol, Hallie Freedman, Matthew L. Pomerantz, Mark M. Cho, Eunyoung Kraft, Peter Preston, Mark A. Wilson, Kathryn M. Michael Gaziano, J. Sesso, Howard D. Black, Amanda Freedman, Neal D. Huang, Wen-Yi Anema, John G. Kahnoski, Richard J. Lane, Brian R. Noyes, Sabrina L. Petillo, David Teh, Bin Tean Peters, Ulrike White, Emily Anderson, Garnet L. Johnson, Lisa Luo, Juhua Buring, Julie Lee, I-Min Chow, Wong-Ho Moore, Lee E. Wood, Christopher Eisen, Timothy Henrion, Marc Larkin, James Barman, Poulami Leibovich, Bradley C. Choueiri, Toni K. Mark Lathrop, G. Rothman, Nathaniel Deleuze, Jean-Francois McKay, James D. Parker, Alexander S. Wu, Xifeng Houlston, Richard S. Brennan, Paul Chanock, Stephen J. Genome-wide association study identifies multiple risk loci for renal cell carcinoma |
| title | Genome-wide association study identifies multiple risk loci for renal cell carcinoma |
| title_full | Genome-wide association study identifies multiple risk loci for renal cell carcinoma |
| title_fullStr | Genome-wide association study identifies multiple risk loci for renal cell carcinoma |
| title_full_unstemmed | Genome-wide association study identifies multiple risk loci for renal cell carcinoma |
| title_short | Genome-wide association study identifies multiple risk loci for renal cell carcinoma |
| title_sort | genome-wide association study identifies multiple risk loci for renal cell carcinoma |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472706/ https://www.ncbi.nlm.nih.gov/pubmed/28598434 http://dx.doi.org/10.1038/ncomms15724 |
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