Transgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of Alzheimer's disease

Defects in p21-activated kinase (PAK) lead to dendritic spine abnormalities and are sufficient to cause cognition impairment. The decrease in PAK in the brain of Alzheimer's disease (AD) patients is suspected to underlie synaptic and dendritic disturbances associated with its clinical expressio...

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Detalles Bibliográficos
Autores principales: Bories, Cyril, Arsenault, Dany, Lemire, Myriam, Tremblay, Cyntia, De Koninck, Yves, Calon, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472739/
https://www.ncbi.nlm.nih.gov/pubmed/28522792
http://dx.doi.org/10.18632/aging.101239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472739/
https://www.ncbi.nlm.nih.gov/pubmed/28522792
http://dx.doi.org/10.18632/aging.101239

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