Cargando…

Transgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of Alzheimer's disease

Defects in p21-activated kinase (PAK) lead to dendritic spine abnormalities and are sufficient to cause cognition impairment. The decrease in PAK in the brain of Alzheimer's disease (AD) patients is suspected to underlie synaptic and dendritic disturbances associated with its clinical expressio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bories, Cyril, Arsenault, Dany, Lemire, Myriam, Tremblay, Cyntia, De Koninck, Yves, Calon, Frédéric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472739/ https://www.ncbi.nlm.nih.gov/pubmed/28522792 http://dx.doi.org/10.18632/aging.101239

Ejemplares similares

Sex-Dependent Alterations in Social Behaviour and Cortical Synaptic Activity Coincide at Different Ages in a Model of Alzheimer’s Disease
por: Bories, Cyril, et al.
Publicado: (2012)

DHA Improves Cognition and Prevents Dysfunction of Entorhinal Cortex Neurons in 3xTg-AD Mice
por: Arsenault, Dany, et al.
Publicado: (2011)

Sex-dependent alterations in the physiology of entorhinal cortex neurons in old heterozygous 3xTg-AD mice
por: Arsenault, Dany, et al.
Publicado: (2020)

Tetrahydrobiopterin Improves Recognition Memory in the Triple-Transgenic Mouse Model of Alzheimer’s Disease, Without Altering Amyloid-β and Tau Pathologies
por: Fanet, Hortense, et al.
Publicado: (2021)

IVIg protects the 3xTg-AD mouse model of Alzheimer’s disease from memory deficit and Aβ pathology
por: St-Amour, Isabelle, et al.
Publicado: (2014)

Interaction of transactive response DNA binding protein 43 with nuclear factor κB in mild cognitive impairment with episodic memory deficits
por: Ohta, Yasuyuki, et al.
Publicado: (2014)

A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments
por: Bonin, Robert P, et al.
Publicado: (2014)

Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations
por: Bianchi, Sarah, et al.
Publicado: (2016)

PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport
por: Siddiqui, Nida, et al.
Publicado: (2019)

Tuning Protein Autoinhibition by Domain Destabilization
por: Cho, Jae-Hyun, et al.
Publicado: (2011)

Control of mRNA decapping by autoinhibition
por: Paquette, David R, et al.
Publicado: (2018)

DCLK1 autoinhibition and activation in tumorigenesis
por: Cheng, Linna, et al.
Publicado: (2021)

Inhibitory coupling between inhibitory interneurons in the spinal cord dorsal horn
por: Labrakakis, Charalampos, et al.
Publicado: (2009)

Evidence of Filamin A loss of solubility at the prodromal stage of neuropathologically-defined Alzheimer’s disease
por: Aumont, Etienne, et al.
Publicado: (2022)

In vivo axonal transport deficits in a mouse model of fronto-temporal dementia
por: Majid, Tabassum, et al.
Publicado: (2014)

Fronto-striatal glutamate in children with Tourette's disorder and attention-deficit/hyperactivity disorder()
por: Naaijen, Jilly, et al.
Publicado: (2016)

Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model
por: Wang, Xu, et al.
Publicado: (2010)

Structural Basis for ESCRT-III Protein Autoinhibition
por: Bajorek, Monika, et al.
Publicado: (2009)

Autoinhibition by Iodide Ion in the Methionine–Iodine Reaction
por: Xu, Li, et al.
Publicado: (2020)

The Architecture of Talin1 Reveals an Autoinhibition Mechanism
por: Dedden, Dirk, et al.
Publicado: (2019)

Allosteric regulation of autoinhibition and activation of c-Abl
por: Liu, Yonglan, et al.
Publicado: (2022)

Structure of LRRK1 and mechanisms of autoinhibition and activation
por: Reimer, Janice M., et al.
Publicado: (2023)

Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells
por: Levert, Stéphanie, et al.
Publicado: (2022)

Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice
por: Pascual-Lucas, Maria, et al.
Publicado: (2014)

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy
por: Singh, Balvindar, et al.
Publicado: (2019)

Impact of long- and short-range fibre depletion on the cognitive deficits of fronto-temporal dementia
por: Savard, Melissa, et al.
Publicado: (2022)

Association of Neuropathological Markers in the Parietal Cortex With Antemortem Cognitive Function in Persons With Mild Cognitive Impairment and Alzheimer Disease
por: Tremblay, Cyntia, et al.
Publicado: (2017)

Autoinhibition of the formin Cappuccino in the absence of canonical autoinhibitory domains
por: Bor, Batbileg, et al.
Publicado: (2012)

Phosphorylation Controls Autoinhibition of Cytoplasmic Linker Protein-170
por: Lee, Ho-Sup, et al.
Publicado: (2010)

Structure of the human Parkin ligase domain in an autoinhibited state
por: Wauer, Tobias, et al.
Publicado: (2013)

Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain
por: Wang, Xin, et al.
Publicado: (2014)

Structural insight into the mechanism of synergistic autoinhibition of SAD kinases
por: Wu, Jing-Xiang, et al.
Publicado: (2015)

Substrate Recognition and Autoinhibition in the Central Ribonuclease RNase E
por: Bandyra, Katarzyna J., et al.
Publicado: (2018)

Autoinhibition of TRPV6 Channel and Regulation by PIP2
por: Cai, Ruiqi, et al.
Publicado: (2020)

Cytoplasmic Autoinhibition in HCN Channels is Regulated by the Transmembrane Region
por: Page, Dana A., et al.
Publicado: (2020)

Cryo-EM structure of the autoinhibited state of myosin-2
por: Heissler, Sarah M., et al.
Publicado: (2021)

PH domain-mediated autoinhibition and oncogenic activation of Akt
por: Bae, Hwan, et al.
Publicado: (2022)

Autoinhibited transient, gated, and cascaded dynamic transcription of RNAs
por: Li, Zhenzhen, et al.
Publicado: (2022)

Molecular architecture of the autoinhibited kinesin-1 lambda particle
por: Weijman, Johannes F., et al.
Publicado: (2022)

Dietary intake of branched-chain amino acids in a mouse model of Alzheimer's disease: Effects on survival, behavior, and neuropathology
por: Tournissac, Marine, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2ie9f6ek1adqsipd159ki53jep