Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency

We sought to identify the impacts of Friedreich's ataxia (FRDA) on cardiomyocytes. FRDA is an autosomal recessive degenerative condition with neuronal and non-neuronal manifestations, the latter including progressive cardiomyopathy of the left ventricle, the leading cause of death in FRDA. Litt...

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Detalles Bibliográficos
Autores principales: Crombie, Duncan E., Curl, Claire L., Raaijmakers, Antonia JA, Sivakumaran, Priyadharshini, Kulkarni, Tejal, Wong, Raymond CB, Minami, Itsunari, Evans-Galea, Marguerite V., Lim, Shiang Y., Delbridge, Lea, Corben, Louise A., Dottori, Mirella, Nakatsuji, Norio, Trounce, Ian A., Hewitt, Alex W., Delatycki, Martin B., Pera, Martin F., Pébay, Alice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472743/
https://www.ncbi.nlm.nih.gov/pubmed/28562313
http://dx.doi.org/10.18632/aging.101247

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