Synthesis and preliminary PET imaging of (11)C and (18)F isotopologues of the ROS1/ALK inhibitor lorlatinib

Lorlatinib (PF-06463922) is a next-generation small-molecule inhibitor of the orphan receptor tyrosine kinase c-ros oncogene 1 (ROS1), which has a kinase domain that is physiologically related to anaplastic lymphoma kinase (ALK), and is undergoing Phase I/II clinical trial investigations for non-sma...

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Detalles Bibliográficos
Autores principales: Collier, Thomas Lee, Normandin, Marc D., Stephenson, Nickeisha A., Livni, Eli, Liang, Steven H., Wooten, Dustin W., Esfahani, Shadi A., Stabin, Michael G., Mahmood, Umar, Chen, Jianqing, Wang, Wei, Maresca, Kevin, Waterhouse, Rikki N., El Fakhri, Georges, Richardson, Paul, Vasdev, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472746/
https://www.ncbi.nlm.nih.gov/pubmed/28594000
http://dx.doi.org/10.1038/ncomms15761

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