Insights into Hunter syndrome from the structure of iduronate-2-sulfatase

Hunter syndrome is a rare but devastating childhood disease caused by mutations in the IDS gene encoding iduronate-2-sulfatase, a crucial enzyme in the lysosomal degradation pathway of dermatan sulfate and heparan sulfate. These complex glycosaminoglycans have important roles in cell adhesion, growt...

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Detalles Bibliográficos
Autores principales: Demydchuk, Mykhaylo, Hill, Chris H., Zhou, Aiwu, Bunkóczi, Gábor, Stein, Penelope E., Marchesan, Denis, Deane, Janet E., Read, Randy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472762/
https://www.ncbi.nlm.nih.gov/pubmed/28593992
http://dx.doi.org/10.1038/ncomms15786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472762/
https://www.ncbi.nlm.nih.gov/pubmed/28593992
http://dx.doi.org/10.1038/ncomms15786

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