Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity

Regulatory T (Treg) cells are important for the maintenance of immune homoeostasis and prevention of autoimmune diseases. Epigenetic modifications have been reported to modulate autoimmunity by altering Treg cell fate. Here we show that the H3K4 methyltransferase Ash1l facilitates TGF-β-induced Treg...

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Detalles Bibliográficos
Autores principales: Xia, Meng, Liu, Juan, Liu, Shuxun, Chen, Kun, Lin, Hongyu, Jiang, Minghong, Xu, Xiaoqing, Xue, Yiquan, Liu, Wei, Gu, Yan, Zhang, Xiang, Li, Zhiqing, Yi, Lin, Qian, Youcun, Zhou, Chen, Li, Ru, Zhang, Xuan, Li, Zhanguo, Cao, Xuetao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472765/
https://www.ncbi.nlm.nih.gov/pubmed/28598443
http://dx.doi.org/10.1038/ncomms15818

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