Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia

Cell-autonomous B-cell receptor (BcR)-mediated signalling is a hallmark feature of the neoplastic B lymphocytes in chronic lymphocytic leukaemia (CLL). Here we elucidate the structural basis of autonomous activation of CLL B cells, showing that BcR immunoglobulins initiate intracellular signalling t...

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Detalles Bibliográficos
Autores principales: Minici, Claudia, Gounari, Maria, Übelhart, Rudolf, Scarfò, Lydia, Dühren-von Minden, Marcus, Schneider, Dunja, Tasdogan, Alpaslan, Alkhatib, Alabbas, Agathangelidis, Andreas, Ntoufa, Stavroula, Chiorazzi, Nicholas, Jumaa, Hassan, Stamatopoulos, Kostas, Ghia, Paolo, Degano, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472768/
https://www.ncbi.nlm.nih.gov/pubmed/28598442
http://dx.doi.org/10.1038/ncomms15746

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