Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice

Lrfn2/SALM1 is a PSD-95-interacting synapse adhesion molecule, and human LRFN2 is associated with learning disabilities. However its role in higher brain function and underlying mechanisms remain unknown. Here, we show that Lrfn2 knockout mice exhibit autism-like behavioural abnormalities, including...

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Detalles Bibliográficos
Autores principales: Morimura, Naoko, Yasuda, Hiroki, Yamaguchi, Kazuhiko, Katayama, Kei-ichi, Hatayama, Minoru, Tomioka, Naoko H., Odagawa, Maya, Kamiya, Akiko, Iwayama, Yoshimi, Maekawa, Motoko, Nakamura, Kazuhiko, Matsuzaki, Hideo, Tsujii, Masatsugu, Yamada, Kazuyuki, Yoshikawa, Takeo, Aruga, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472790/
https://www.ncbi.nlm.nih.gov/pubmed/28604739
http://dx.doi.org/10.1038/ncomms15800

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