The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites

Double-strand breaks (DSBs) are repaired through two major pathways, homology-directed recombination (HDR) and non-homologous end joining (NHEJ). While HDR can only occur in S/G2, NHEJ can happen in all cell cycle phases (except mitosis). How then is the repair choice made in S/G2 cells? Here we pro...

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Detalles Bibliográficos
Autores principales: Ha, Kyungsoo, Ma, Chengxian, Lin, Han, Tang, Lichun, Lian, Zhusheng, Zhao, Fang, Li, Ju-Mei, Zhen, Bei, Pei, Huadong, Han, Suxia, Malumbres, Marcos, Jin, Jianping, Chen, Huan, Zhao, Yongxiang, Zhu, Qing, Zhang, Pumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472795/
https://www.ncbi.nlm.nih.gov/pubmed/28604711
http://dx.doi.org/10.1038/ncomms15751

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