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Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial

BACKGROUND: Head injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to injury or infection with the aim of improving clinical outcome. The aim...

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Autores principales: Rai, Vineya Rai Hakumat, Phang, Lee Fern, Sia, Sheau Fung, Amir, Amirah, Veerakumaran, Jeyaganesh S., Kassim, Mustafa Kassim Abdulazez, Othman, Rafidah, Tah, Pei Chien, Loh, Pui San, Jailani, Mohamad Irfan Othman, Ong, Gracie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472912/
https://www.ncbi.nlm.nih.gov/pubmed/28619005
http://dx.doi.org/10.1186/s12871-017-0369-4
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author Rai, Vineya Rai Hakumat
Phang, Lee Fern
Sia, Sheau Fung
Amir, Amirah
Veerakumaran, Jeyaganesh S.
Kassim, Mustafa Kassim Abdulazez
Othman, Rafidah
Tah, Pei Chien
Loh, Pui San
Jailani, Mohamad Irfan Othman
Ong, Gracie
author_facet Rai, Vineya Rai Hakumat
Phang, Lee Fern
Sia, Sheau Fung
Amir, Amirah
Veerakumaran, Jeyaganesh S.
Kassim, Mustafa Kassim Abdulazez
Othman, Rafidah
Tah, Pei Chien
Loh, Pui San
Jailani, Mohamad Irfan Othman
Ong, Gracie
author_sort Rai, Vineya Rai Hakumat
collection PubMed
description BACKGROUND: Head injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to injury or infection with the aim of improving clinical outcome. The aim of the present study was to evaluate the effect of an immunonutrition on biomarkers (IL-6, glutathione, CRP, total protein and albumin) in traumatic brain injury patients. METHODS: Thirty six patients with head injury admitted to neurosurgical ICU in University Malaya Medical Centre were recruited for this study, over a 6-month period from July 2014 to January 2015. Patients were randomized to receive either an immunonutrition (Group A) or a standard (Group B) enteral feed. Levels of biomarkers were measured at day 1, 5 and 7 of enteral feeding. RESULTS: Patients in Group A showed significant reduction of IL-6 at day 5 (p < 0.001) with concurrent rise in glutathione levels (p = 0.049). Patients in Group A also demonstrated a significant increase of total protein level at the end of the study (day 7). CONCLUSION: These findings indicate the potential of immunonutrition reducing cytokines and increasing antioxidant indices in patients with TBI. However, further studies incorporating patient outcomes are needed to determine its overall clinical benefits. TRIAL REGISTRATION: National Medical Research Register (NMRR) ID: 14–1430-23,171. ClinicalTrials.gov identifier: NCT03166449.
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spelling pubmed-54729122017-06-21 Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial Rai, Vineya Rai Hakumat Phang, Lee Fern Sia, Sheau Fung Amir, Amirah Veerakumaran, Jeyaganesh S. Kassim, Mustafa Kassim Abdulazez Othman, Rafidah Tah, Pei Chien Loh, Pui San Jailani, Mohamad Irfan Othman Ong, Gracie BMC Anesthesiol Research Article BACKGROUND: Head injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to injury or infection with the aim of improving clinical outcome. The aim of the present study was to evaluate the effect of an immunonutrition on biomarkers (IL-6, glutathione, CRP, total protein and albumin) in traumatic brain injury patients. METHODS: Thirty six patients with head injury admitted to neurosurgical ICU in University Malaya Medical Centre were recruited for this study, over a 6-month period from July 2014 to January 2015. Patients were randomized to receive either an immunonutrition (Group A) or a standard (Group B) enteral feed. Levels of biomarkers were measured at day 1, 5 and 7 of enteral feeding. RESULTS: Patients in Group A showed significant reduction of IL-6 at day 5 (p < 0.001) with concurrent rise in glutathione levels (p = 0.049). Patients in Group A also demonstrated a significant increase of total protein level at the end of the study (day 7). CONCLUSION: These findings indicate the potential of immunonutrition reducing cytokines and increasing antioxidant indices in patients with TBI. However, further studies incorporating patient outcomes are needed to determine its overall clinical benefits. TRIAL REGISTRATION: National Medical Research Register (NMRR) ID: 14–1430-23,171. ClinicalTrials.gov identifier: NCT03166449. BioMed Central 2017-06-15 /pmc/articles/PMC5472912/ /pubmed/28619005 http://dx.doi.org/10.1186/s12871-017-0369-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Rai, Vineya Rai Hakumat
Phang, Lee Fern
Sia, Sheau Fung
Amir, Amirah
Veerakumaran, Jeyaganesh S.
Kassim, Mustafa Kassim Abdulazez
Othman, Rafidah
Tah, Pei Chien
Loh, Pui San
Jailani, Mohamad Irfan Othman
Ong, Gracie
Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial
title Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial
title_full Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial
title_fullStr Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial
title_full_unstemmed Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial
title_short Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial
title_sort effects of immunonutrition on biomarkers in traumatic brain injury patients in malaysia: a prospective randomized controlled trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472912/
https://www.ncbi.nlm.nih.gov/pubmed/28619005
http://dx.doi.org/10.1186/s12871-017-0369-4
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