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Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial
BACKGROUND: Head injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to injury or infection with the aim of improving clinical outcome. The aim...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472912/ https://www.ncbi.nlm.nih.gov/pubmed/28619005 http://dx.doi.org/10.1186/s12871-017-0369-4 |
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author | Rai, Vineya Rai Hakumat Phang, Lee Fern Sia, Sheau Fung Amir, Amirah Veerakumaran, Jeyaganesh S. Kassim, Mustafa Kassim Abdulazez Othman, Rafidah Tah, Pei Chien Loh, Pui San Jailani, Mohamad Irfan Othman Ong, Gracie |
author_facet | Rai, Vineya Rai Hakumat Phang, Lee Fern Sia, Sheau Fung Amir, Amirah Veerakumaran, Jeyaganesh S. Kassim, Mustafa Kassim Abdulazez Othman, Rafidah Tah, Pei Chien Loh, Pui San Jailani, Mohamad Irfan Othman Ong, Gracie |
author_sort | Rai, Vineya Rai Hakumat |
collection | PubMed |
description | BACKGROUND: Head injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to injury or infection with the aim of improving clinical outcome. The aim of the present study was to evaluate the effect of an immunonutrition on biomarkers (IL-6, glutathione, CRP, total protein and albumin) in traumatic brain injury patients. METHODS: Thirty six patients with head injury admitted to neurosurgical ICU in University Malaya Medical Centre were recruited for this study, over a 6-month period from July 2014 to January 2015. Patients were randomized to receive either an immunonutrition (Group A) or a standard (Group B) enteral feed. Levels of biomarkers were measured at day 1, 5 and 7 of enteral feeding. RESULTS: Patients in Group A showed significant reduction of IL-6 at day 5 (p < 0.001) with concurrent rise in glutathione levels (p = 0.049). Patients in Group A also demonstrated a significant increase of total protein level at the end of the study (day 7). CONCLUSION: These findings indicate the potential of immunonutrition reducing cytokines and increasing antioxidant indices in patients with TBI. However, further studies incorporating patient outcomes are needed to determine its overall clinical benefits. TRIAL REGISTRATION: National Medical Research Register (NMRR) ID: 14–1430-23,171. ClinicalTrials.gov identifier: NCT03166449. |
format | Online Article Text |
id | pubmed-5472912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54729122017-06-21 Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial Rai, Vineya Rai Hakumat Phang, Lee Fern Sia, Sheau Fung Amir, Amirah Veerakumaran, Jeyaganesh S. Kassim, Mustafa Kassim Abdulazez Othman, Rafidah Tah, Pei Chien Loh, Pui San Jailani, Mohamad Irfan Othman Ong, Gracie BMC Anesthesiol Research Article BACKGROUND: Head injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to injury or infection with the aim of improving clinical outcome. The aim of the present study was to evaluate the effect of an immunonutrition on biomarkers (IL-6, glutathione, CRP, total protein and albumin) in traumatic brain injury patients. METHODS: Thirty six patients with head injury admitted to neurosurgical ICU in University Malaya Medical Centre were recruited for this study, over a 6-month period from July 2014 to January 2015. Patients were randomized to receive either an immunonutrition (Group A) or a standard (Group B) enteral feed. Levels of biomarkers were measured at day 1, 5 and 7 of enteral feeding. RESULTS: Patients in Group A showed significant reduction of IL-6 at day 5 (p < 0.001) with concurrent rise in glutathione levels (p = 0.049). Patients in Group A also demonstrated a significant increase of total protein level at the end of the study (day 7). CONCLUSION: These findings indicate the potential of immunonutrition reducing cytokines and increasing antioxidant indices in patients with TBI. However, further studies incorporating patient outcomes are needed to determine its overall clinical benefits. TRIAL REGISTRATION: National Medical Research Register (NMRR) ID: 14–1430-23,171. ClinicalTrials.gov identifier: NCT03166449. BioMed Central 2017-06-15 /pmc/articles/PMC5472912/ /pubmed/28619005 http://dx.doi.org/10.1186/s12871-017-0369-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Rai, Vineya Rai Hakumat Phang, Lee Fern Sia, Sheau Fung Amir, Amirah Veerakumaran, Jeyaganesh S. Kassim, Mustafa Kassim Abdulazez Othman, Rafidah Tah, Pei Chien Loh, Pui San Jailani, Mohamad Irfan Othman Ong, Gracie Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial |
title | Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial |
title_full | Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial |
title_fullStr | Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial |
title_full_unstemmed | Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial |
title_short | Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial |
title_sort | effects of immunonutrition on biomarkers in traumatic brain injury patients in malaysia: a prospective randomized controlled trial |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472912/ https://www.ncbi.nlm.nih.gov/pubmed/28619005 http://dx.doi.org/10.1186/s12871-017-0369-4 |
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