A Review of Non-operative Treatments for Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombus

Portal vein tumor thrombus (PVTT) frequently occurs with the progression of hepatocellular carcinoma (HCC) and is an important factor in determining the prognosis of HCC. In many cases of HCC with advanced PVTT, treatment is difficult because the tumor has considerable extension into the liver, and...

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Detalles Bibliográficos
Autores principales: Moriguchi, Michihisa, Furuta, Mitsuhiro, Itoh, Yoshito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: XIA & HE Publishing Inc. 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472939/
https://www.ncbi.nlm.nih.gov/pubmed/28660156
http://dx.doi.org/10.14218/JCTH.2016.00075
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author Moriguchi, Michihisa
Furuta, Mitsuhiro
Itoh, Yoshito
author_facet Moriguchi, Michihisa
Furuta, Mitsuhiro
Itoh, Yoshito
author_sort Moriguchi, Michihisa
collection PubMed
description Portal vein tumor thrombus (PVTT) frequently occurs with the progression of hepatocellular carcinoma (HCC) and is an important factor in determining the prognosis of HCC. In many cases of HCC with advanced PVTT, treatment is difficult because the tumor has considerable extension into the liver, and portal hypertension is a frequent complication. The standard therapy for unresectable HCC with advanced PVTT is sorafenib therapy in patients with good hepatic function. However, the outcomes of sorafenib therapy are not completely satisfactory, making the development of another therapy an urgent task. Therefore, this review aims to summarize non-operative treatments for HCC with advanced PVTT and discuss future perspectives based on those therapies, including therapies still being developed.
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spelling pubmed-54729392017-06-28 A Review of Non-operative Treatments for Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombus Moriguchi, Michihisa Furuta, Mitsuhiro Itoh, Yoshito J Clin Transl Hepatol Review Article Portal vein tumor thrombus (PVTT) frequently occurs with the progression of hepatocellular carcinoma (HCC) and is an important factor in determining the prognosis of HCC. In many cases of HCC with advanced PVTT, treatment is difficult because the tumor has considerable extension into the liver, and portal hypertension is a frequent complication. The standard therapy for unresectable HCC with advanced PVTT is sorafenib therapy in patients with good hepatic function. However, the outcomes of sorafenib therapy are not completely satisfactory, making the development of another therapy an urgent task. Therefore, this review aims to summarize non-operative treatments for HCC with advanced PVTT and discuss future perspectives based on those therapies, including therapies still being developed. XIA & HE Publishing Inc. 2017-04-12 2017-06-28 /pmc/articles/PMC5472939/ /pubmed/28660156 http://dx.doi.org/10.14218/JCTH.2016.00075 Text en © 2017 Authors. http://creativecommons.org/licenses/by-nc/4.0/ This article has been published under the terms of Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0), which permits noncommercial unrestricted use, distribution, and reproduction in any medium, provided that the following statement is provided. “This article has been published in Journal of Clinical and Translational Hepatology at DOI: 10.14218/JCTH.2016.00075 and can also be viewed on the Journal’s website at http://www.jcthnet.com”.
spellingShingle Review Article
Moriguchi, Michihisa
Furuta, Mitsuhiro
Itoh, Yoshito
A Review of Non-operative Treatments for Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombus
title A Review of Non-operative Treatments for Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombus
title_full A Review of Non-operative Treatments for Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombus
title_fullStr A Review of Non-operative Treatments for Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombus
title_full_unstemmed A Review of Non-operative Treatments for Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombus
title_short A Review of Non-operative Treatments for Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombus
title_sort review of non-operative treatments for hepatocellular carcinoma with advanced portal vein tumor thrombus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472939/
https://www.ncbi.nlm.nih.gov/pubmed/28660156
http://dx.doi.org/10.14218/JCTH.2016.00075
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