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Rapid deterioration of Mooren’s ulcers after conjunctival flap: a review of 2 cases

BACKGROUND: Conjunctival flaps are a widely used treatment for numerous corneal ulcers that are caused by microorganismal infections. However, whether it can be performed on immune-mediated corneal ulcers is controversial. CASE PRESENTATION: We present two cases of Mooren’s ulcer that were treated u...

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Autores principales: Li, Saiqun, Deng, Yuqing, Du, Caiyuan, Huang, Haixiang, Zhong, Jing, Chen, Ling, Wang, Bowen, Yuan, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472947/
https://www.ncbi.nlm.nih.gov/pubmed/28619029
http://dx.doi.org/10.1186/s12886-017-0488-1
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author Li, Saiqun
Deng, Yuqing
Du, Caiyuan
Huang, Haixiang
Zhong, Jing
Chen, Ling
Wang, Bowen
Yuan, Jin
author_facet Li, Saiqun
Deng, Yuqing
Du, Caiyuan
Huang, Haixiang
Zhong, Jing
Chen, Ling
Wang, Bowen
Yuan, Jin
author_sort Li, Saiqun
collection PubMed
description BACKGROUND: Conjunctival flaps are a widely used treatment for numerous corneal ulcers that are caused by microorganismal infections. However, whether it can be performed on immune-mediated corneal ulcers is controversial. CASE PRESENTATION: We present two cases of Mooren’s ulcer that were treated using conjunctival flap in an attempt to prevent further corneal perforation at their local hospital. A rapid acceleration in ulcer progression was observed after a conjunctival flap was applied. Ultimately, the two patients underwent corneal transplantation, which required the postoperative use of topical immunosuppressants and resulted in a final cure. In the current report, we also discussed this incorrect surgical choice via a review of conventional interventions that are used to treat Mooren’s ulcer. CONCLUSIONS: These two cases demonstrate that keratoplasty combined with topical immunosuppressants is effective in treating Mooren’s ulcer. Application of conjunctival flaps or autografting could promote progression of ulceration in Mooren’s ulcers.
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spelling pubmed-54729472017-06-21 Rapid deterioration of Mooren’s ulcers after conjunctival flap: a review of 2 cases Li, Saiqun Deng, Yuqing Du, Caiyuan Huang, Haixiang Zhong, Jing Chen, Ling Wang, Bowen Yuan, Jin BMC Ophthalmol Case Report BACKGROUND: Conjunctival flaps are a widely used treatment for numerous corneal ulcers that are caused by microorganismal infections. However, whether it can be performed on immune-mediated corneal ulcers is controversial. CASE PRESENTATION: We present two cases of Mooren’s ulcer that were treated using conjunctival flap in an attempt to prevent further corneal perforation at their local hospital. A rapid acceleration in ulcer progression was observed after a conjunctival flap was applied. Ultimately, the two patients underwent corneal transplantation, which required the postoperative use of topical immunosuppressants and resulted in a final cure. In the current report, we also discussed this incorrect surgical choice via a review of conventional interventions that are used to treat Mooren’s ulcer. CONCLUSIONS: These two cases demonstrate that keratoplasty combined with topical immunosuppressants is effective in treating Mooren’s ulcer. Application of conjunctival flaps or autografting could promote progression of ulceration in Mooren’s ulcers. BioMed Central 2017-06-15 /pmc/articles/PMC5472947/ /pubmed/28619029 http://dx.doi.org/10.1186/s12886-017-0488-1 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Li, Saiqun
Deng, Yuqing
Du, Caiyuan
Huang, Haixiang
Zhong, Jing
Chen, Ling
Wang, Bowen
Yuan, Jin
Rapid deterioration of Mooren’s ulcers after conjunctival flap: a review of 2 cases
title Rapid deterioration of Mooren’s ulcers after conjunctival flap: a review of 2 cases
title_full Rapid deterioration of Mooren’s ulcers after conjunctival flap: a review of 2 cases
title_fullStr Rapid deterioration of Mooren’s ulcers after conjunctival flap: a review of 2 cases
title_full_unstemmed Rapid deterioration of Mooren’s ulcers after conjunctival flap: a review of 2 cases
title_short Rapid deterioration of Mooren’s ulcers after conjunctival flap: a review of 2 cases
title_sort rapid deterioration of mooren’s ulcers after conjunctival flap: a review of 2 cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472947/
https://www.ncbi.nlm.nih.gov/pubmed/28619029
http://dx.doi.org/10.1186/s12886-017-0488-1
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