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Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway

BACKGROUND: Presenilins play a major role in the pathogenesis of Alzheimer’s disease, in which the hippocampus is particularly vulnerable. Previous studies of Presenilin function in the synapse, however, focused exclusively on the hippocampal Schaffer collateral (SC) pathway. Whether Presenilins pla...

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Detalles Bibliográficos
Autores principales:	Lee, Sang Hun, Lutz, David, Mossalam, Mohanad, Bolshakov, Vadim Y., Frotscher, Michael, Shen, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472971/ https://www.ncbi.nlm.nih.gov/pubmed/28619096 http://dx.doi.org/10.1186/s13024-017-0189-5

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