Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors

BACKGROUND: A high rate of glycolysis leading to elevated lactate content has been linked to poor clinical outcomes in patients with head and neck and cervical cancer treated with radiotherapy. Although the biological explanation for this relationship between lactate and treatment response remains u...

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Detalles Bibliográficos
Autores principales: Leung, Eric, Cairns, Rob A., Chaudary, Naz, Vellanki, Ravi N., Kalliomaki, Tuula, Moriyama, Eduardo H., Mujcic, Hilda, Wilson, Brian C., Wouters, Bradly G., Hill, Richard, Milosevic, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473006/
https://www.ncbi.nlm.nih.gov/pubmed/28619042
http://dx.doi.org/10.1186/s12885-017-3402-6

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