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Smaller outer diameter of atherosclerotic middle cerebral artery associated with RNF213 c.14576G>A Variant (rs112735431)
BACKGROUND: Intracranial atherosclerosis (ICAS) involves diverse histologies and several remodeling patterns. Ring finger protein 213 (RNF213) c.14576G>A variant (rs112735431), recently reported to be associated with ICAS, may be linked with negative remodeling (outer diameter – reducing morpholo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473080/ https://www.ncbi.nlm.nih.gov/pubmed/28695051 http://dx.doi.org/10.4103/sni.sni_59_17 |
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author | Hongo, Hiroki Miyawaki, Satoru Imai, Hideaki Shinya, Yuki Ono, Hideaki Mori, Harushi Nakatomi, Hirofumi Kunimatsu, Akira Saito, Nobuhito |
author_facet | Hongo, Hiroki Miyawaki, Satoru Imai, Hideaki Shinya, Yuki Ono, Hideaki Mori, Harushi Nakatomi, Hirofumi Kunimatsu, Akira Saito, Nobuhito |
author_sort | Hongo, Hiroki |
collection | PubMed |
description | BACKGROUND: Intracranial atherosclerosis (ICAS) involves diverse histologies and several remodeling patterns. Ring finger protein 213 (RNF213) c.14576G>A variant (rs112735431), recently reported to be associated with ICAS, may be linked with negative remodeling (outer diameter – reducing morphological alteration) of intracranial arteries. This study investigated the outer diameter of atherosclerotic middle cerebral artery (MCA). METHODS: Patients with unilateral atherosclerotic MCA stenosis/occlusion were enrolled in this single-hospital-based case-control study at The University of Tokyo Hospital. The patients were divided into two groups by the presence of RNF213 c.14576G>A (variant group and wild-type group) and the outer diameter of the MCA was measured with high-resolution magnetic resonance imaging. RESULTS: Twenty-eight patients with the wild type and 19 patients with the variant type were included. The outer diameter of the stenotic side MCA was smaller in the variant group than in the wild-type group (P = 8.3 × 10(-6)). The outer diameter of the normal side MCA was also smaller in the variant group than in the wild-type group (P = 5.2 × 10(-3)). The ratio of stenotic side to normal side was also smaller in the variant group than in the wild-type group (P = 1.5 × 10(-5)). CONCLUSIONS: This study indicates that RNF213 c.14576G>A is associated with negative remodeling of ICAS. |
format | Online Article Text |
id | pubmed-5473080 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-54730802017-07-10 Smaller outer diameter of atherosclerotic middle cerebral artery associated with RNF213 c.14576G>A Variant (rs112735431) Hongo, Hiroki Miyawaki, Satoru Imai, Hideaki Shinya, Yuki Ono, Hideaki Mori, Harushi Nakatomi, Hirofumi Kunimatsu, Akira Saito, Nobuhito Surg Neurol Int Neurovascular: Original Article BACKGROUND: Intracranial atherosclerosis (ICAS) involves diverse histologies and several remodeling patterns. Ring finger protein 213 (RNF213) c.14576G>A variant (rs112735431), recently reported to be associated with ICAS, may be linked with negative remodeling (outer diameter – reducing morphological alteration) of intracranial arteries. This study investigated the outer diameter of atherosclerotic middle cerebral artery (MCA). METHODS: Patients with unilateral atherosclerotic MCA stenosis/occlusion were enrolled in this single-hospital-based case-control study at The University of Tokyo Hospital. The patients were divided into two groups by the presence of RNF213 c.14576G>A (variant group and wild-type group) and the outer diameter of the MCA was measured with high-resolution magnetic resonance imaging. RESULTS: Twenty-eight patients with the wild type and 19 patients with the variant type were included. The outer diameter of the stenotic side MCA was smaller in the variant group than in the wild-type group (P = 8.3 × 10(-6)). The outer diameter of the normal side MCA was also smaller in the variant group than in the wild-type group (P = 5.2 × 10(-3)). The ratio of stenotic side to normal side was also smaller in the variant group than in the wild-type group (P = 1.5 × 10(-5)). CONCLUSIONS: This study indicates that RNF213 c.14576G>A is associated with negative remodeling of ICAS. Medknow Publications & Media Pvt Ltd 2017-06-05 /pmc/articles/PMC5473080/ /pubmed/28695051 http://dx.doi.org/10.4103/sni.sni_59_17 Text en Copyright: © 2017 Surgical Neurology International http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Neurovascular: Original Article Hongo, Hiroki Miyawaki, Satoru Imai, Hideaki Shinya, Yuki Ono, Hideaki Mori, Harushi Nakatomi, Hirofumi Kunimatsu, Akira Saito, Nobuhito Smaller outer diameter of atherosclerotic middle cerebral artery associated with RNF213 c.14576G>A Variant (rs112735431) |
title | Smaller outer diameter of atherosclerotic middle cerebral artery associated with RNF213 c.14576G>A Variant (rs112735431) |
title_full | Smaller outer diameter of atherosclerotic middle cerebral artery associated with RNF213 c.14576G>A Variant (rs112735431) |
title_fullStr | Smaller outer diameter of atherosclerotic middle cerebral artery associated with RNF213 c.14576G>A Variant (rs112735431) |
title_full_unstemmed | Smaller outer diameter of atherosclerotic middle cerebral artery associated with RNF213 c.14576G>A Variant (rs112735431) |
title_short | Smaller outer diameter of atherosclerotic middle cerebral artery associated with RNF213 c.14576G>A Variant (rs112735431) |
title_sort | smaller outer diameter of atherosclerotic middle cerebral artery associated with rnf213 c.14576g>a variant (rs112735431) |
topic | Neurovascular: Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473080/ https://www.ncbi.nlm.nih.gov/pubmed/28695051 http://dx.doi.org/10.4103/sni.sni_59_17 |
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