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Regulatory BC1 RNA in cognitive control
Dendritic regulatory BC1 RNA is a non-protein-coding (npc) RNA that operates in the translational control of gene expression. The absence of BC1 RNA in BC1 knockout (KO) animals causes translational dysregulation that entails neuronal phenotypic alterations including prolonged epileptiform discharge...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473108/ https://www.ncbi.nlm.nih.gov/pubmed/28620074 http://dx.doi.org/10.1101/lm.045427.117 |
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author | Iacoangeli, Anna Dosunmu, Aderemi Eom, Taesun Stefanov, Dimitre G. Tiedge, Henri |
author_facet | Iacoangeli, Anna Dosunmu, Aderemi Eom, Taesun Stefanov, Dimitre G. Tiedge, Henri |
author_sort | Iacoangeli, Anna |
collection | PubMed |
description | Dendritic regulatory BC1 RNA is a non-protein-coding (npc) RNA that operates in the translational control of gene expression. The absence of BC1 RNA in BC1 knockout (KO) animals causes translational dysregulation that entails neuronal phenotypic alterations including prolonged epileptiform discharges, audiogenic seizure activity in vivo, and excessive cortical oscillations in the γ frequency band. Here we asked whether BC1 RNA control is also required for higher brain functions such as learning, memory, or cognition. To address this question, we used odor/object attentional set shifting tasks in which prefrontal cortical performance was assessed in a series of discrimination and conflict learning sessions. Results obtained in these behavioral trials indicate that BC1 KO animals were significantly impaired in their cognitive flexibility. When faced with conflicting information sources, BC1 KO animals committed regressive errors as they were compromised in their ability to disengage from recently acquired memories even though recall of such memories was in conflict with new situational context. The observed cognitive deficits are reminiscent of those previously described in subtypes of human autism spectrum disorders. |
format | Online Article Text |
id | pubmed-5473108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-54731082018-07-01 Regulatory BC1 RNA in cognitive control Iacoangeli, Anna Dosunmu, Aderemi Eom, Taesun Stefanov, Dimitre G. Tiedge, Henri Learn Mem Research Dendritic regulatory BC1 RNA is a non-protein-coding (npc) RNA that operates in the translational control of gene expression. The absence of BC1 RNA in BC1 knockout (KO) animals causes translational dysregulation that entails neuronal phenotypic alterations including prolonged epileptiform discharges, audiogenic seizure activity in vivo, and excessive cortical oscillations in the γ frequency band. Here we asked whether BC1 RNA control is also required for higher brain functions such as learning, memory, or cognition. To address this question, we used odor/object attentional set shifting tasks in which prefrontal cortical performance was assessed in a series of discrimination and conflict learning sessions. Results obtained in these behavioral trials indicate that BC1 KO animals were significantly impaired in their cognitive flexibility. When faced with conflicting information sources, BC1 KO animals committed regressive errors as they were compromised in their ability to disengage from recently acquired memories even though recall of such memories was in conflict with new situational context. The observed cognitive deficits are reminiscent of those previously described in subtypes of human autism spectrum disorders. Cold Spring Harbor Laboratory Press 2017-07 /pmc/articles/PMC5473108/ /pubmed/28620074 http://dx.doi.org/10.1101/lm.045427.117 Text en © 2017 Iacoangeli et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Iacoangeli, Anna Dosunmu, Aderemi Eom, Taesun Stefanov, Dimitre G. Tiedge, Henri Regulatory BC1 RNA in cognitive control |
title | Regulatory BC1 RNA in cognitive control |
title_full | Regulatory BC1 RNA in cognitive control |
title_fullStr | Regulatory BC1 RNA in cognitive control |
title_full_unstemmed | Regulatory BC1 RNA in cognitive control |
title_short | Regulatory BC1 RNA in cognitive control |
title_sort | regulatory bc1 rna in cognitive control |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473108/ https://www.ncbi.nlm.nih.gov/pubmed/28620074 http://dx.doi.org/10.1101/lm.045427.117 |
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