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Regulatory BC1 RNA in cognitive control

Dendritic regulatory BC1 RNA is a non-protein-coding (npc) RNA that operates in the translational control of gene expression. The absence of BC1 RNA in BC1 knockout (KO) animals causes translational dysregulation that entails neuronal phenotypic alterations including prolonged epileptiform discharge...

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Autores principales: Iacoangeli, Anna, Dosunmu, Aderemi, Eom, Taesun, Stefanov, Dimitre G., Tiedge, Henri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473108/
https://www.ncbi.nlm.nih.gov/pubmed/28620074
http://dx.doi.org/10.1101/lm.045427.117
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author Iacoangeli, Anna
Dosunmu, Aderemi
Eom, Taesun
Stefanov, Dimitre G.
Tiedge, Henri
author_facet Iacoangeli, Anna
Dosunmu, Aderemi
Eom, Taesun
Stefanov, Dimitre G.
Tiedge, Henri
author_sort Iacoangeli, Anna
collection PubMed
description Dendritic regulatory BC1 RNA is a non-protein-coding (npc) RNA that operates in the translational control of gene expression. The absence of BC1 RNA in BC1 knockout (KO) animals causes translational dysregulation that entails neuronal phenotypic alterations including prolonged epileptiform discharges, audiogenic seizure activity in vivo, and excessive cortical oscillations in the γ frequency band. Here we asked whether BC1 RNA control is also required for higher brain functions such as learning, memory, or cognition. To address this question, we used odor/object attentional set shifting tasks in which prefrontal cortical performance was assessed in a series of discrimination and conflict learning sessions. Results obtained in these behavioral trials indicate that BC1 KO animals were significantly impaired in their cognitive flexibility. When faced with conflicting information sources, BC1 KO animals committed regressive errors as they were compromised in their ability to disengage from recently acquired memories even though recall of such memories was in conflict with new situational context. The observed cognitive deficits are reminiscent of those previously described in subtypes of human autism spectrum disorders.
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spelling pubmed-54731082018-07-01 Regulatory BC1 RNA in cognitive control Iacoangeli, Anna Dosunmu, Aderemi Eom, Taesun Stefanov, Dimitre G. Tiedge, Henri Learn Mem Research Dendritic regulatory BC1 RNA is a non-protein-coding (npc) RNA that operates in the translational control of gene expression. The absence of BC1 RNA in BC1 knockout (KO) animals causes translational dysregulation that entails neuronal phenotypic alterations including prolonged epileptiform discharges, audiogenic seizure activity in vivo, and excessive cortical oscillations in the γ frequency band. Here we asked whether BC1 RNA control is also required for higher brain functions such as learning, memory, or cognition. To address this question, we used odor/object attentional set shifting tasks in which prefrontal cortical performance was assessed in a series of discrimination and conflict learning sessions. Results obtained in these behavioral trials indicate that BC1 KO animals were significantly impaired in their cognitive flexibility. When faced with conflicting information sources, BC1 KO animals committed regressive errors as they were compromised in their ability to disengage from recently acquired memories even though recall of such memories was in conflict with new situational context. The observed cognitive deficits are reminiscent of those previously described in subtypes of human autism spectrum disorders. Cold Spring Harbor Laboratory Press 2017-07 /pmc/articles/PMC5473108/ /pubmed/28620074 http://dx.doi.org/10.1101/lm.045427.117 Text en © 2017 Iacoangeli et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research
Iacoangeli, Anna
Dosunmu, Aderemi
Eom, Taesun
Stefanov, Dimitre G.
Tiedge, Henri
Regulatory BC1 RNA in cognitive control
title Regulatory BC1 RNA in cognitive control
title_full Regulatory BC1 RNA in cognitive control
title_fullStr Regulatory BC1 RNA in cognitive control
title_full_unstemmed Regulatory BC1 RNA in cognitive control
title_short Regulatory BC1 RNA in cognitive control
title_sort regulatory bc1 rna in cognitive control
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473108/
https://www.ncbi.nlm.nih.gov/pubmed/28620074
http://dx.doi.org/10.1101/lm.045427.117
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