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Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells

AIM: To examine the influence on apoptotic mechanisms following inhibition of polo-like kinases as therapeutically approach for cholangiocellular cancer treatment. METHODS: As most cholangiocarcinomas are chemotherapy-resistant due to mechanisms preventing tumor cell death, we investigated the effec...

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Detalles Bibliográficos
Autores principales:	Sydor, Svenja, Jafoui, Sami, Wingerter, Lena, Swoboda, Sandra, Mertens, Joachim C, Gerken, Guido, Canbay, Ali, Paul, Andreas, Fingas, Christian D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Baishideng Publishing Group Inc 2017
Materias:	Basic Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473120/ https://www.ncbi.nlm.nih.gov/pubmed/28652654 http://dx.doi.org/10.3748/wjg.v23.i22.4007

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