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A rare case of apical hypertrophic cardiomyopathy (AHCM)

Apical hypertrophic cardiomyopathy is a rare form of hypertrophic cardiomyopathy that involves thickening of the distal portion of the left ventricular wall. Most commonly seen in the Japan, with a prevalence rate of about 15% of all HCM patient, its incidence in the USA is approximately 3% of HCM c...

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Autores principales: Mirabbasi, Seyed Abbas, Khalighi, Koroush, Mukkamala, Suresh, Kodali, Archana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473187/
https://www.ncbi.nlm.nih.gov/pubmed/28638577
http://dx.doi.org/10.1080/20009666.2017.1324238
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author Mirabbasi, Seyed Abbas
Khalighi, Koroush
Mukkamala, Suresh
Kodali, Archana
author_facet Mirabbasi, Seyed Abbas
Khalighi, Koroush
Mukkamala, Suresh
Kodali, Archana
author_sort Mirabbasi, Seyed Abbas
collection PubMed
description Apical hypertrophic cardiomyopathy is a rare form of hypertrophic cardiomyopathy that involves thickening of the distal portion of the left ventricular wall. Most commonly seen in the Japan, with a prevalence rate of about 15% of all HCM patient, its incidence in the USA is approximately 3% of HCM cases. We report a case of a 46-year-old woman with history of hypertension who presented to emergency department with worsening dyspnea and orthopnea with features of left ventricular hypertrophy (LVH) and diffuse large T-wave inversions in the lateral leads on a 12-lead ECG. Further work up revealed severe concentric LVH, with near obliteration of the LV cavity. Ventriculogram showed severe symmetric hypertrophy of the mid to lower septum, extending to the apex of left ventricle with significant pressure gradient of at least 160 mmHg across the apex to mid septal cavity, with no significant gradient across the left ventricular outflow tract. These findings were consistent with apical hypertrophic cardiomyopathy. She was treated with verapamil and metoprolol and has remained asymptomatic over last 2.5 years of follow-up. Although the clinical presentation of AHCM can be variable and nonspecific; however, hallmark findings on ECG and echo can be extremely important in its diagnosis. Abbreviations: AHCM: Apical hypertrophic cardiomyopathy; ECG: Electrocardiogram; LVH: Left ventricular hypertrophy; LVOT: Left ventricular outflow tract
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spelling pubmed-54731872017-06-21 A rare case of apical hypertrophic cardiomyopathy (AHCM) Mirabbasi, Seyed Abbas Khalighi, Koroush Mukkamala, Suresh Kodali, Archana J Community Hosp Intern Med Perspect Case Reports Apical hypertrophic cardiomyopathy is a rare form of hypertrophic cardiomyopathy that involves thickening of the distal portion of the left ventricular wall. Most commonly seen in the Japan, with a prevalence rate of about 15% of all HCM patient, its incidence in the USA is approximately 3% of HCM cases. We report a case of a 46-year-old woman with history of hypertension who presented to emergency department with worsening dyspnea and orthopnea with features of left ventricular hypertrophy (LVH) and diffuse large T-wave inversions in the lateral leads on a 12-lead ECG. Further work up revealed severe concentric LVH, with near obliteration of the LV cavity. Ventriculogram showed severe symmetric hypertrophy of the mid to lower septum, extending to the apex of left ventricle with significant pressure gradient of at least 160 mmHg across the apex to mid septal cavity, with no significant gradient across the left ventricular outflow tract. These findings were consistent with apical hypertrophic cardiomyopathy. She was treated with verapamil and metoprolol and has remained asymptomatic over last 2.5 years of follow-up. Although the clinical presentation of AHCM can be variable and nonspecific; however, hallmark findings on ECG and echo can be extremely important in its diagnosis. Abbreviations: AHCM: Apical hypertrophic cardiomyopathy; ECG: Electrocardiogram; LVH: Left ventricular hypertrophy; LVOT: Left ventricular outflow tract Taylor & Francis 2017-06-06 /pmc/articles/PMC5473187/ /pubmed/28638577 http://dx.doi.org/10.1080/20009666.2017.1324238 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Mirabbasi, Seyed Abbas
Khalighi, Koroush
Mukkamala, Suresh
Kodali, Archana
A rare case of apical hypertrophic cardiomyopathy (AHCM)
title A rare case of apical hypertrophic cardiomyopathy (AHCM)
title_full A rare case of apical hypertrophic cardiomyopathy (AHCM)
title_fullStr A rare case of apical hypertrophic cardiomyopathy (AHCM)
title_full_unstemmed A rare case of apical hypertrophic cardiomyopathy (AHCM)
title_short A rare case of apical hypertrophic cardiomyopathy (AHCM)
title_sort rare case of apical hypertrophic cardiomyopathy (ahcm)
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473187/
https://www.ncbi.nlm.nih.gov/pubmed/28638577
http://dx.doi.org/10.1080/20009666.2017.1324238
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