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Molecular and phenotypic biomarkers of aging
Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging are valuable tools to measure physiological age, assess the extent of ‘healthy aging’, and potentially predict health span and life span for an individual. Given the complex nature of the aging process, the bi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473407/ https://www.ncbi.nlm.nih.gov/pubmed/28663789 http://dx.doi.org/10.12688/f1000research.10692.1 |
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author | Xia, Xian Chen, Weiyang McDermott, Joseph Han, Jing-Dong Jackie |
author_facet | Xia, Xian Chen, Weiyang McDermott, Joseph Han, Jing-Dong Jackie |
author_sort | Xia, Xian |
collection | PubMed |
description | Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging are valuable tools to measure physiological age, assess the extent of ‘healthy aging’, and potentially predict health span and life span for an individual. Given the complex nature of the aging process, the biomarkers of aging are multilayered and multifaceted. Here, we review the phenotypic and molecular biomarkers of aging. Identifying and using biomarkers of aging to improve human health, prevent age-associated diseases, and extend healthy life span are now facilitated by the fast-growing capacity of multilevel cross-sectional and longitudinal data acquisition, storage, and analysis, particularly for data related to general human populations. Combined with artificial intelligence and machine learning techniques, reliable panels of biomarkers of aging will have tremendous potential to improve human health in aging societies. |
format | Online Article Text |
id | pubmed-5473407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-54734072017-06-28 Molecular and phenotypic biomarkers of aging Xia, Xian Chen, Weiyang McDermott, Joseph Han, Jing-Dong Jackie F1000Res Review Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging are valuable tools to measure physiological age, assess the extent of ‘healthy aging’, and potentially predict health span and life span for an individual. Given the complex nature of the aging process, the biomarkers of aging are multilayered and multifaceted. Here, we review the phenotypic and molecular biomarkers of aging. Identifying and using biomarkers of aging to improve human health, prevent age-associated diseases, and extend healthy life span are now facilitated by the fast-growing capacity of multilevel cross-sectional and longitudinal data acquisition, storage, and analysis, particularly for data related to general human populations. Combined with artificial intelligence and machine learning techniques, reliable panels of biomarkers of aging will have tremendous potential to improve human health in aging societies. F1000Research 2017-06-09 /pmc/articles/PMC5473407/ /pubmed/28663789 http://dx.doi.org/10.12688/f1000research.10692.1 Text en Copyright: © 2017 Xia X et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Xia, Xian Chen, Weiyang McDermott, Joseph Han, Jing-Dong Jackie Molecular and phenotypic biomarkers of aging |
title | Molecular and phenotypic biomarkers of aging |
title_full | Molecular and phenotypic biomarkers of aging |
title_fullStr | Molecular and phenotypic biomarkers of aging |
title_full_unstemmed | Molecular and phenotypic biomarkers of aging |
title_short | Molecular and phenotypic biomarkers of aging |
title_sort | molecular and phenotypic biomarkers of aging |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473407/ https://www.ncbi.nlm.nih.gov/pubmed/28663789 http://dx.doi.org/10.12688/f1000research.10692.1 |
work_keys_str_mv | AT xiaxian molecularandphenotypicbiomarkersofaging AT chenweiyang molecularandphenotypicbiomarkersofaging AT mcdermottjoseph molecularandphenotypicbiomarkersofaging AT hanjingdongjackie molecularandphenotypicbiomarkersofaging |