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Cytomegalovirus Infection With Retinitis After Brentuximab Vedotin Treatment for CD30(+) Lymphoma

Brentuximab vedotin is an antibody-conjugated chemotherapy targeting CD30 indicated in treatment of several lymphomas. We report the first 3 cases of cytomegalovirus severe infections with retinitis following this treatment. Evolution was favorable, but relapse occurred after treatment rechallenge....

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Autores principales: Tudesq, Jean-Jacques, Vincent, Laure, Lebrun, Julie, Hicheri, Yosr, Gabellier, Ludovic, Busetto, Timothé, Merle, Corinne, Fegueux, Nathalie, Ceballos, Patrice, Quittet, Philippe, Navarro, Robert, Hillaire-Buys, Dominique, Cartron, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473439/
https://www.ncbi.nlm.nih.gov/pubmed/28638848
http://dx.doi.org/10.1093/ofid/ofx091
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author Tudesq, Jean-Jacques
Vincent, Laure
Lebrun, Julie
Hicheri, Yosr
Gabellier, Ludovic
Busetto, Timothé
Merle, Corinne
Fegueux, Nathalie
Ceballos, Patrice
Quittet, Philippe
Navarro, Robert
Hillaire-Buys, Dominique
Cartron, Guillaume
author_facet Tudesq, Jean-Jacques
Vincent, Laure
Lebrun, Julie
Hicheri, Yosr
Gabellier, Ludovic
Busetto, Timothé
Merle, Corinne
Fegueux, Nathalie
Ceballos, Patrice
Quittet, Philippe
Navarro, Robert
Hillaire-Buys, Dominique
Cartron, Guillaume
author_sort Tudesq, Jean-Jacques
collection PubMed
description Brentuximab vedotin is an antibody-conjugated chemotherapy targeting CD30 indicated in treatment of several lymphomas. We report the first 3 cases of cytomegalovirus severe infections with retinitis following this treatment. Evolution was favorable, but relapse occurred after treatment rechallenge. We suggest vigilance about cytomegalovirus in patients treated with brentuximab vedotin.
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spelling pubmed-54734392017-06-21 Cytomegalovirus Infection With Retinitis After Brentuximab Vedotin Treatment for CD30(+) Lymphoma Tudesq, Jean-Jacques Vincent, Laure Lebrun, Julie Hicheri, Yosr Gabellier, Ludovic Busetto, Timothé Merle, Corinne Fegueux, Nathalie Ceballos, Patrice Quittet, Philippe Navarro, Robert Hillaire-Buys, Dominique Cartron, Guillaume Open Forum Infect Dis Brief Report Brentuximab vedotin is an antibody-conjugated chemotherapy targeting CD30 indicated in treatment of several lymphomas. We report the first 3 cases of cytomegalovirus severe infections with retinitis following this treatment. Evolution was favorable, but relapse occurred after treatment rechallenge. We suggest vigilance about cytomegalovirus in patients treated with brentuximab vedotin. Oxford University Press 2017-04-05 /pmc/articles/PMC5473439/ /pubmed/28638848 http://dx.doi.org/10.1093/ofid/ofx091 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Tudesq, Jean-Jacques
Vincent, Laure
Lebrun, Julie
Hicheri, Yosr
Gabellier, Ludovic
Busetto, Timothé
Merle, Corinne
Fegueux, Nathalie
Ceballos, Patrice
Quittet, Philippe
Navarro, Robert
Hillaire-Buys, Dominique
Cartron, Guillaume
Cytomegalovirus Infection With Retinitis After Brentuximab Vedotin Treatment for CD30(+) Lymphoma
title Cytomegalovirus Infection With Retinitis After Brentuximab Vedotin Treatment for CD30(+) Lymphoma
title_full Cytomegalovirus Infection With Retinitis After Brentuximab Vedotin Treatment for CD30(+) Lymphoma
title_fullStr Cytomegalovirus Infection With Retinitis After Brentuximab Vedotin Treatment for CD30(+) Lymphoma
title_full_unstemmed Cytomegalovirus Infection With Retinitis After Brentuximab Vedotin Treatment for CD30(+) Lymphoma
title_short Cytomegalovirus Infection With Retinitis After Brentuximab Vedotin Treatment for CD30(+) Lymphoma
title_sort cytomegalovirus infection with retinitis after brentuximab vedotin treatment for cd30(+) lymphoma
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473439/
https://www.ncbi.nlm.nih.gov/pubmed/28638848
http://dx.doi.org/10.1093/ofid/ofx091
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