The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature

Although both growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signaling were shown to regulate life span in lower organisms, the role of GH signaling in human longevity remains unclear. Because a GH receptor exon 3 deletion (d3-GHR) appears to modulate GH sensitivity in humans, we hypot...

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Detalles Bibliográficos
Autores principales: Ben-Avraham, Danny, Govindaraju, Diddahally R., Budagov, Temuri, Fradin, Delphine, Durda, Peter, Liu, Bing, Ott, Sandy, Gutman, Danielle, Sharvit, Lital, Kaplan, Robert, Bougnères, Pierre, Reiner, Alex, Shuldiner, Alan R., Cohen, Pinchas, Barzilai, Nir, Atzmon, Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473676/
https://www.ncbi.nlm.nih.gov/pubmed/28630896
http://dx.doi.org/10.1126/sciadv.1602025

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