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The history behind successful uterine transplantation in humans
This paper aimed to describe the basic aspects of uterine transplant (UTx) research in humans, including preliminary experiences in rodents and domestic species. Studies in rats, domestic species, and non-human primates validated and optimized the UTx procedure in terms of its surgical aspects, immu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Brazilian Society of Assisted Reproduction
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473706/ https://www.ncbi.nlm.nih.gov/pubmed/28609280 http://dx.doi.org/10.5935/1518-0557.20170028 |
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author | Castellón, Luis Arturo Ruvalcaba Amador, Martha Isolina García González, Roberto Enrique Díaz Eduardo, Montoya Sarmiento Jorge Díaz-García, César Kvarnström, Niclas Bränström, Mats |
author_facet | Castellón, Luis Arturo Ruvalcaba Amador, Martha Isolina García González, Roberto Enrique Díaz Eduardo, Montoya Sarmiento Jorge Díaz-García, César Kvarnström, Niclas Bränström, Mats |
author_sort | Castellón, Luis Arturo Ruvalcaba |
collection | PubMed |
description | This paper aimed to describe the basic aspects of uterine transplant (UTx) research in humans, including preliminary experiences in rodents and domestic species. Studies in rats, domestic species, and non-human primates validated and optimized the UTx procedure in terms of its surgical aspects, immunosuppression, rejection diagnosis, peculiarities of pregnancy in immunosuppressed patients, and patients with special uterine conditions. In animal species, the first live birth from UTx was achieved in a syngeneic mouse model in 2003. Twenty-five UTx procedures have been performed in humans. The first two cases were unsuccessful, but established the need for rigorous research to improve success rates. As a result of a controlled clinical study under a strictly designed research protocol, nine subsequent UTx procedures have resulted in six healthy live births, the first of them in 2014. Further failed UTx procedures have been performed in China, Czech Republic, Brazil, Germany, and the United States, most of which using living donors. Albeit still an experimental procedure in, UTx is the first potential alternative for the treatment of absolute uterine factor infertility (AUFI). |
format | Online Article Text |
id | pubmed-5473706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Brazilian Society of Assisted Reproduction |
record_format | MEDLINE/PubMed |
spelling | pubmed-54737062017-06-27 The history behind successful uterine transplantation in humans Castellón, Luis Arturo Ruvalcaba Amador, Martha Isolina García González, Roberto Enrique Díaz Eduardo, Montoya Sarmiento Jorge Díaz-García, César Kvarnström, Niclas Bränström, Mats JBRA Assist Reprod Update Article This paper aimed to describe the basic aspects of uterine transplant (UTx) research in humans, including preliminary experiences in rodents and domestic species. Studies in rats, domestic species, and non-human primates validated and optimized the UTx procedure in terms of its surgical aspects, immunosuppression, rejection diagnosis, peculiarities of pregnancy in immunosuppressed patients, and patients with special uterine conditions. In animal species, the first live birth from UTx was achieved in a syngeneic mouse model in 2003. Twenty-five UTx procedures have been performed in humans. The first two cases were unsuccessful, but established the need for rigorous research to improve success rates. As a result of a controlled clinical study under a strictly designed research protocol, nine subsequent UTx procedures have resulted in six healthy live births, the first of them in 2014. Further failed UTx procedures have been performed in China, Czech Republic, Brazil, Germany, and the United States, most of which using living donors. Albeit still an experimental procedure in, UTx is the first potential alternative for the treatment of absolute uterine factor infertility (AUFI). Brazilian Society of Assisted Reproduction 2017 /pmc/articles/PMC5473706/ /pubmed/28609280 http://dx.doi.org/10.5935/1518-0557.20170028 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Update Article Castellón, Luis Arturo Ruvalcaba Amador, Martha Isolina García González, Roberto Enrique Díaz Eduardo, Montoya Sarmiento Jorge Díaz-García, César Kvarnström, Niclas Bränström, Mats The history behind successful uterine transplantation in humans |
title | The history behind successful uterine transplantation in
humans |
title_full | The history behind successful uterine transplantation in
humans |
title_fullStr | The history behind successful uterine transplantation in
humans |
title_full_unstemmed | The history behind successful uterine transplantation in
humans |
title_short | The history behind successful uterine transplantation in
humans |
title_sort | history behind successful uterine transplantation in
humans |
topic | Update Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473706/ https://www.ncbi.nlm.nih.gov/pubmed/28609280 http://dx.doi.org/10.5935/1518-0557.20170028 |
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