Cargando…
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits
Deep sequence-based imputation can enhance the discovery power of genome-wide association studies by assessing previously unexplored variation across the common- and low-frequency spectra. We applied a hybrid whole-genome sequencing (WGS) and deep imputation approach to examine the broader allelic a...
Ejemplares similares
-
A novel variant in GLIS3 is associated with osteoarthritis
por: Casalone, Elisabetta, et al.
Publicado: (2018) -
Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
por: Southam, Lorraine, et al.
Publicado: (2017) -
In search of low-frequency and rare variants affecting complex traits
por: Panoutsopoulou, Kalliope, et al.
Publicado: (2013) -
A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates
por: Tachmazidou, Ioanna, et al.
Publicado: (2013) -
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank
por: Tachmazidou, Ioanna, et al.
Publicado: (2019)