Highly functional T-cell receptor repertoires are abundant in stem memory T cells and highly shared among individuals

To expand our knowledge of the ontogeny of the T-cell receptor (TCR) repertoire of antigen-specific T-cell subsets, we combined next-generation deep sequencing and single-cell multiplex clonotype analysis to evaluate the diversity and frequency of paired TCRs, their functions and whether clonotypic...

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Detalles Bibliográficos
Autores principales: Miyama, Takahiko, Kawase, Takakazu, Kitaura, Kazutaka, Chishaki, Ren, Shibata, Masashi, Oshima, Kumi, Hamana, Hiroshi, Kishi, Hiroyuki, Muraguchi, Atsushi, Kuzushima, Kiyotaka, Saji, Hiroh, Shin-I, Tadasu, Suzuki, Ryuji, Ichinohe, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473819/
https://www.ncbi.nlm.nih.gov/pubmed/28623251
http://dx.doi.org/10.1038/s41598-017-03855-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473819/
https://www.ncbi.nlm.nih.gov/pubmed/28623251
http://dx.doi.org/10.1038/s41598-017-03855-x

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