Cargando…
Revealing protein networks and gene-drug connectivity in cancer from direct information
The connection between genetic variation and drug response has long been explored to facilitate the optimization and personalization of cancer therapy. Crucial to the identification of drug response related genetic features is the ability to separate indirect correlations from direct correlations ac...
Autores principales: | Jiang, Xian-Li, Martinez-Ledesma, Emmanuel, Morcos, Faruck |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473890/ https://www.ncbi.nlm.nih.gov/pubmed/28623316 http://dx.doi.org/10.1038/s41598-017-04001-3 |
Ejemplares similares
-
Information Theory in Molecular Evolution: From Models to Structures and Dynamics
por: Morcos, Faruck
Publicado: (2021) -
Evolutionary entrenchment in immune proteins selects against stabilizing mutations
por: Morcos, Faruck
Publicado: (2022) -
Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions
por: Jiang, Xian-Li, et al.
Publicado: (2021) -
Sequence co-evolutionary information is a natural partner to minimally-frustrated models of biomolecular dynamics
por: Noel, Jeffrey K, et al.
Publicado: (2016) -
Latent generative landscapes as maps of functional diversity in protein sequence space
por: Ziegler, Cheyenne, et al.
Publicado: (2023)