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Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions
Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O(2) environments, elevated rates of glycolysis support critical cellular mechanisms such as cell survival. The purpose of this study was to analyze the contribution of...
Autores principales: | Del Rey, Manuel J., Valín, Álvaro, Usategui, Alicia, García-Herrero, Carmen M., Sánchez-Aragó, María, Cuezva, José M., Galindo, María, Bravo, Beatriz, Cañete, Juan D., Blanco, Francisco J., Criado, Gabriel, Pablos, José L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473902/ https://www.ncbi.nlm.nih.gov/pubmed/28623342 http://dx.doi.org/10.1038/s41598-017-03921-4 |
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