Machine Learning and Network Analysis of Molecular Dynamics Trajectories Reveal Two Chains of Red/Ox-specific Residue Interactions in Human Protein Disulfide Isomerase

The human protein disulfide isomerase (hPDI), is an essential four-domain multifunctional enzyme. As a result of disulfide shuffling in its terminal domains, hPDI exists in two oxidation states with different conformational preferences which are important for substrate binding and functional activit...

Descripción completa

Detalles Bibliográficos
Autores principales: Karamzadeh, Razieh, Karimi-Jafari, Mohammad Hossein, Sharifi-Zarchi, Ali, Chitsaz, Hamidreza, Salekdeh, Ghasem Hosseini, Moosavi-Movahedi, Ali Akbar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473932/
https://www.ncbi.nlm.nih.gov/pubmed/28623339
http://dx.doi.org/10.1038/s41598-017-03966-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473932/
https://www.ncbi.nlm.nih.gov/pubmed/28623339
http://dx.doi.org/10.1038/s41598-017-03966-5

Ejemplares similares