Machine Learning and Network Analysis of Molecular Dynamics Trajectories Reveal Two Chains of Red/Ox-specific Residue Interactions in Human Protein Disulfide Isomerase

The human protein disulfide isomerase (hPDI), is an essential four-domain multifunctional enzyme. As a result of disulfide shuffling in its terminal domains, hPDI exists in two oxidation states with different conformational preferences which are important for substrate binding and functional activit...

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Detalles Bibliográficos
Autores principales: Karamzadeh, Razieh, Karimi-Jafari, Mohammad Hossein, Sharifi-Zarchi, Ali, Chitsaz, Hamidreza, Salekdeh, Ghasem Hosseini, Moosavi-Movahedi, Ali Akbar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473932/
https://www.ncbi.nlm.nih.gov/pubmed/28623339
http://dx.doi.org/10.1038/s41598-017-03966-5

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