Safety/tolerability of the anti-semaphorin 4D Antibody VX15/2503 in a randomized phase 1 trial

OBJECTIVE: To evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of VX15/2503 in a randomized, single-dose, dose-escalation, double-blind, placebo-controlled study enrolling adult patients with MS. METHODS: Single IV doses of VX15/2503 or placebo were administered. T...

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Detalles Bibliográficos
Autores principales: LaGanke, Christopher, Samkoff, Lawrence, Edwards, Keith, Jung Henson, Lily, Repovic, Pavle, Lynch, Sharon, Stone, Lael, Mattson, David, Galluzzi, Aaron, Fisher, Terrence L., Reilly, Christine, Winter, Laurie A., Leonard, John E., Zauderer, Maurice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473956/
https://www.ncbi.nlm.nih.gov/pubmed/28642891
http://dx.doi.org/10.1212/NXI.0000000000000367

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