Cargando…

Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis

BACKGROUND: Despite the important role that microRNAs (miRNAs) play in immunity and inflammation, their involvement in systemic sclerosis (SSc) remains poorly characterized. miRNA-155 (miR-155) plays a role in pulmonary fibrosis and its expression can be induced with interleukin (IL)-1β. SSc fibrobl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Artlett, Carol M., Sassi-Gaha, Sihem, Hope, Jennifer L., Feghali-Bostwick, Carol A., Katsikis, Peter D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473986/ https://www.ncbi.nlm.nih.gov/pubmed/28623945 http://dx.doi.org/10.1186/s13075-017-1331-z

Ejemplares similares

Targeting the unfolded protein response, XBP1, and the NLRP3 inflammasome in fibrosis and cancer
por: Overley-Adamson, Beth, et al.
Publicado: (2014)

The Role of the NLRP3 Inflammasome in Fibrosis
por: Artlett, Carol M
Publicado: (2012)

The Mechanism and Regulation of the NLRP3 Inflammasome during Fibrosis
por: Artlett, Carol M.
Publicado: (2022)

Fibroblasts in fibrosis: novel roles and mediators
por: Kendall, Ryan T., et al.
Publicado: (2014)

The MicroRNA miR-155 Is Essential in Fibrosis
por: Eissa, Mousa G., et al.
Publicado: (2019)

The Molecular Mechanisms of Systemic Sclerosis-Associated Lung Fibrosis
por: Mouawad, Joe E., et al.
Publicado: (2023)

Chimeric cells of maternal origin do not appear to be pathogenic in the juvenile idiopathic inflammatory myopathies or muscular dystrophy
por: Artlett, Carol M., et al.
Publicado: (2015)

382 The Role of the IL-6-IGF-II Axis in Systemic Sclerosis-Associated Lung Fibrosis
por: Adewale, Adegboyega Timothy, et al.
Publicado: (2023)

miR-155 in the progression of lung fibrosis in systemic sclerosis
por: Christmann, Romy B., et al.
Publicado: (2016)

The Membrane-Associated Adaptor Protein DOK5 Is Upregulated in Systemic Sclerosis and Associated with IGFBP-5-Induced Fibrosis
por: Yasuoka, Hidekata, et al.
Publicado: (2014)

Genetics of systemic sclerosis: recent advances
por: Ramos, Paula S., et al.
Publicado: (2015)

Antifibrotic Effects of Roscovitine in Normal and Scleroderma Fibroblasts
por: Steinman, Richard A., et al.
Publicado: (2012)

2027 The role of lysyl oxidase in systemic sclerosis-associated lung fibrosis
por: Nguyen, Xinh-Xinh, et al.
Publicado: (2018)

IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF
por: Su, Yunyun, et al.
Publicado: (2015)

Animal models of systemic sclerosis: their utility and limitations
por: Artlett, Carol M
Publicado: (2014)

Insulin-Like Growth Factor Binding Proteins-3 and -5: Central Mediators of Fibrosis and Promising New Therapeutic Targets
por: Veraldi, Kristen L, et al.
Publicado: (2012)

A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies COL22A1 as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast Transition
por: Watanabe, Tomoya, et al.
Publicado: (2019)

Therapeutic Challenges And Advances In The Management Of Systemic Sclerosis-Related Pulmonary Arterial Hypertension (SSc-PAH)
por: Argula, Rahul G, et al.
Publicado: (2019)

Identification of Impacted Pathways and Transcriptomic Markers as Potential Mediators of Pulmonary Fibrosis in Transgenic Mice Expressing Human IGFBP5
por: Nguyen, Xinh-Xinh, et al.
Publicado: (2021)

Long intergenic non-coding RNAs regulate human lung fibroblast function: Implications for idiopathic pulmonary fibrosis
por: Hadjicharalambous, Marina R., et al.
Publicado: (2019)

Modification of Collagen by 3-Deoxyglucosone Alters Wound Healing through Differential Regulation of p38 MAP Kinase
por: Loughlin, Danielle T., et al.
Publicado: (2011)

PDGF Promotes Dermal Fibroblast Activation via a Novel Mechanism Mediated by Signaling Through MCHR1
por: Takamura, Naoko, et al.
Publicado: (2021)

Decreased caveolin-1 levels contribute to fibrosis and deposition of extracellular IGFBP-5
por: Yamaguchi, Yukie, et al.
Publicado: (2011)

IGFBP-5 Promotes Fibrosis via Increasing Its Own Expression and That of Other Pro-fibrotic Mediators
por: Nguyen, Xinh-Xinh, et al.
Publicado: (2018)

Elucidating the cellular mechanism for E2-induced dermal fibrosis
por: Baker Frost, DeAnna, et al.
Publicado: (2021)

Role of NLRP3 inflammasome in systemic sclerosis
por: Lin, Cong, et al.
Publicado: (2022)

Precursor of Advanced Glycation End Products Mediates ER-Stress-Induced Caspase-3 Activation of Human Dermal Fibroblasts through NAD(P)H Oxidase 4
por: Loughlin, Danielle T., et al.
Publicado: (2010)

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis
por: Wei, Jun, et al.
Publicado: (2010)

Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is K(Ca)3.1-dependent
por: Roach, Katy M, et al.
Publicado: (2014)

Prominence of IL6, IGF, TLR, and Bioenergetics Pathway Perturbation in Lung Tissues of Scleroderma Patients With Pulmonary Fibrosis
por: Renaud, Ludivine, et al.
Publicado: (2020)

Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions
por: Garrett, Sara M., et al.
Publicado: (2019)

The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis
por: Kurowska-Stolarska, Mariola, et al.
Publicado: (2017)

First Characterization of the Transcriptome of Lung Fibroblasts of SSc Patients and Healthy Donors of African Ancestry
por: Renaud, Ludivine, et al.
Publicado: (2023)

Systems Analysis of Transcriptomic and Proteomic Profiles Identifies Novel Regulation of Fibrotic Programs by miRNAs in Pulmonary Fibrosis Fibroblasts
por: Mullenbrock, Steven, et al.
Publicado: (2018)

Differential DNA Methylation Landscape in Skin Fibroblasts from African Americans with Systemic Sclerosis
por: Baker Frost, DeAnna, et al.
Publicado: (2021)

The Role of Autophagy and NLRP3 Inflammasome in Liver Fibrosis
por: Tao, Ye, et al.
Publicado: (2020)

The Role of SOX9 in IGF-II-Mediated Pulmonary Fibrosis
por: Waldrep, Kristy M., et al.
Publicado: (2023)

Optimization of a murine and human tissue model to recapitulate dermal and pulmonary features of systemic sclerosis
por: Watanabe, Tomoya, et al.
Publicado: (2017)

A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis
por: Coward, William R., et al.
Publicado: (2014)

The K(+) Channel K(Ca)3.1 as a Novel Target for Idiopathic Pulmonary Fibrosis
por: Roach, Katy Morgan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_399uf6gdif7hj1ovf2825rmhbf