Histone Deacetylase Inhibitors Interrupt HSP90•RASGRP1 and HSP90•CRAF Interactions to Upregulate BIM and Circumvent Drug Resistance in Lymphoma Cells

Histone deacetylase (HDAC) inhibitors, which are approved for the treatment of cutaneous T cell lymphoma and multiple myeloma, are undergoing evaluation in other lymphoid neoplasms. How they kill susceptible cells is incompletely understood. Here we show that trichostatin A, romidepsin, and panobino...

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Detalles Bibliográficos
Autores principales: Ding, Husheng, Peterson, Kevin L., Correia, Cristina, Koh, Brian, Schneider, Paula A., Nowakowski, Grzegorz S., Kaufmann, Scott H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474223/
https://www.ncbi.nlm.nih.gov/pubmed/27890930
http://dx.doi.org/10.1038/leu.2016.357

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