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Inherited Variation in Cytokine, Acute Phase Response, and Calcium Metabolism Genes Affects Susceptibility to Infective Endocarditis

Infective endocarditis (IE) is a septic inflammation of the endocardium. Recognition of microbial patterns, cytokine and acute phase responses, hemostasis features, and alterations in plasma lipid and calcium profile all have been reported to affect pathogenesis and clinical course of IE. Having rec...

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Autores principales: Ponasenko, Anastasia V., Kutikhin, Anton G., Khutornaya, Maria V., Rutkovskaya, Natalia V., Kondyukova, Natalia V., Odarenko, Yuri N., Kazachek, Yana V., Tsepokina, Anna V., Barbarash, Leonid S., Yuzhalin, Arseniy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474236/
https://www.ncbi.nlm.nih.gov/pubmed/28659664
http://dx.doi.org/10.1155/2017/7962546
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author Ponasenko, Anastasia V.
Kutikhin, Anton G.
Khutornaya, Maria V.
Rutkovskaya, Natalia V.
Kondyukova, Natalia V.
Odarenko, Yuri N.
Kazachek, Yana V.
Tsepokina, Anna V.
Barbarash, Leonid S.
Yuzhalin, Arseniy E.
author_facet Ponasenko, Anastasia V.
Kutikhin, Anton G.
Khutornaya, Maria V.
Rutkovskaya, Natalia V.
Kondyukova, Natalia V.
Odarenko, Yuri N.
Kazachek, Yana V.
Tsepokina, Anna V.
Barbarash, Leonid S.
Yuzhalin, Arseniy E.
author_sort Ponasenko, Anastasia V.
collection PubMed
description Infective endocarditis (IE) is a septic inflammation of the endocardium. Recognition of microbial patterns, cytokine and acute phase responses, hemostasis features, and alterations in plasma lipid and calcium profile all have been reported to affect pathogenesis and clinical course of IE. Having recruited 123 patients with IE and 300 age-, sex-, and ethnicity-matched healthy blood donors, we profiled their genomic DNA for 35 functionally significant polymorphisms within the 22 selected genes involved in the abovementioned pathways, with the further genetic association analysis. We found that the G/A genotype of the rs1143634 polymorphism within the IL1B gene, the G/T genotype of the rs3212227 polymorphism within the IL12B gene, the A/G genotype of the rs1130864 polymorphism within the CRP gene, and the G allele of the rs1801197 polymorphism within the CALCR gene were associated with a decreased risk of IE whereas the T/T genotype of the rs1205 polymorphism within the CRP gene was associated with a higher risk of IE. Furthermore, heterozygous genotypes of the rs1143634 and rs3212227 polymorphisms were associated with the higher plasma levels of IL-1β and IL-12, respectively. Our results indicate that inherited variation in the cytokine, acute phase response, and calcium metabolism pathways may be linked to IE.
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spelling pubmed-54742362017-06-28 Inherited Variation in Cytokine, Acute Phase Response, and Calcium Metabolism Genes Affects Susceptibility to Infective Endocarditis Ponasenko, Anastasia V. Kutikhin, Anton G. Khutornaya, Maria V. Rutkovskaya, Natalia V. Kondyukova, Natalia V. Odarenko, Yuri N. Kazachek, Yana V. Tsepokina, Anna V. Barbarash, Leonid S. Yuzhalin, Arseniy E. Mediators Inflamm Research Article Infective endocarditis (IE) is a septic inflammation of the endocardium. Recognition of microbial patterns, cytokine and acute phase responses, hemostasis features, and alterations in plasma lipid and calcium profile all have been reported to affect pathogenesis and clinical course of IE. Having recruited 123 patients with IE and 300 age-, sex-, and ethnicity-matched healthy blood donors, we profiled their genomic DNA for 35 functionally significant polymorphisms within the 22 selected genes involved in the abovementioned pathways, with the further genetic association analysis. We found that the G/A genotype of the rs1143634 polymorphism within the IL1B gene, the G/T genotype of the rs3212227 polymorphism within the IL12B gene, the A/G genotype of the rs1130864 polymorphism within the CRP gene, and the G allele of the rs1801197 polymorphism within the CALCR gene were associated with a decreased risk of IE whereas the T/T genotype of the rs1205 polymorphism within the CRP gene was associated with a higher risk of IE. Furthermore, heterozygous genotypes of the rs1143634 and rs3212227 polymorphisms were associated with the higher plasma levels of IL-1β and IL-12, respectively. Our results indicate that inherited variation in the cytokine, acute phase response, and calcium metabolism pathways may be linked to IE. Hindawi 2017 2017-06-04 /pmc/articles/PMC5474236/ /pubmed/28659664 http://dx.doi.org/10.1155/2017/7962546 Text en Copyright © 2017 Anastasia V. Ponasenko et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ponasenko, Anastasia V.
Kutikhin, Anton G.
Khutornaya, Maria V.
Rutkovskaya, Natalia V.
Kondyukova, Natalia V.
Odarenko, Yuri N.
Kazachek, Yana V.
Tsepokina, Anna V.
Barbarash, Leonid S.
Yuzhalin, Arseniy E.
Inherited Variation in Cytokine, Acute Phase Response, and Calcium Metabolism Genes Affects Susceptibility to Infective Endocarditis
title Inherited Variation in Cytokine, Acute Phase Response, and Calcium Metabolism Genes Affects Susceptibility to Infective Endocarditis
title_full Inherited Variation in Cytokine, Acute Phase Response, and Calcium Metabolism Genes Affects Susceptibility to Infective Endocarditis
title_fullStr Inherited Variation in Cytokine, Acute Phase Response, and Calcium Metabolism Genes Affects Susceptibility to Infective Endocarditis
title_full_unstemmed Inherited Variation in Cytokine, Acute Phase Response, and Calcium Metabolism Genes Affects Susceptibility to Infective Endocarditis
title_short Inherited Variation in Cytokine, Acute Phase Response, and Calcium Metabolism Genes Affects Susceptibility to Infective Endocarditis
title_sort inherited variation in cytokine, acute phase response, and calcium metabolism genes affects susceptibility to infective endocarditis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474236/
https://www.ncbi.nlm.nih.gov/pubmed/28659664
http://dx.doi.org/10.1155/2017/7962546
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