Cargando…
Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer
Ischemic stroke patients with active cancer are known to have poor clinical outcomes. However, the efficacy and safety of intravenous alteplase (IV t-PA) in this group are still unclear. In this study, we aimed to evaluate whether stroke patients with cancer had poor clinical outcomes after use of I...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474258/ https://www.ncbi.nlm.nih.gov/pubmed/28660209 http://dx.doi.org/10.1155/2017/4635829 |
_version_ | 1783244414788829184 |
---|---|
author | Nam, Ki-Woong Kim, Chi Kyung Kim, Tae Jung An, Sang Joon Oh, Kyungmi Ko, Sang-Bae Yoon, Byung-Woo |
author_facet | Nam, Ki-Woong Kim, Chi Kyung Kim, Tae Jung An, Sang Joon Oh, Kyungmi Ko, Sang-Bae Yoon, Byung-Woo |
author_sort | Nam, Ki-Woong |
collection | PubMed |
description | Ischemic stroke patients with active cancer are known to have poor clinical outcomes. However, the efficacy and safety of intravenous alteplase (IV t-PA) in this group are still unclear. In this study, we aimed to evaluate whether stroke patients with cancer had poor clinical outcomes after use of IV t-PA. We reviewed ischemic stroke patients with active cancer treated with isolated IV t-PA between April 2010 and March 2015 at three national university hospitals from the registry for ischemic stroke in Korea. The clinical outcomes of early neurological deterioration (END), hemorrhagic transformation, in-hospital mortality, 3-month modified Rankin scale (mRS), the National Institutes of Health Stroke Scale (NIHSS) discharge score, and duration of hospitalization were compared. We enrolled a total of 12 patients, and the cohort showed poor outcomes including 4 (33%) END events, 7 (58%) hemorrhagic transformations, 3 (25%) in-hospital mortality cases, and 7 (58%) poor mRS (3–6) scores. Additionally, the cryptogenic stroke group (n = 6) more frequently had high mRS scores (P = 0.043) as well as tendencies for frequent END events, hemorrhagic transformations, in-hospital mortality cases, and higher discharge NIHSS scores without statistical significance. In conclusion, ischemic stroke patients with active cancer, especially those with a cryptogenic mechanism, showed poor clinical outcomes after use of IV t-PA. |
format | Online Article Text |
id | pubmed-5474258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-54742582017-06-28 Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer Nam, Ki-Woong Kim, Chi Kyung Kim, Tae Jung An, Sang Joon Oh, Kyungmi Ko, Sang-Bae Yoon, Byung-Woo Biomed Res Int Research Article Ischemic stroke patients with active cancer are known to have poor clinical outcomes. However, the efficacy and safety of intravenous alteplase (IV t-PA) in this group are still unclear. In this study, we aimed to evaluate whether stroke patients with cancer had poor clinical outcomes after use of IV t-PA. We reviewed ischemic stroke patients with active cancer treated with isolated IV t-PA between April 2010 and March 2015 at three national university hospitals from the registry for ischemic stroke in Korea. The clinical outcomes of early neurological deterioration (END), hemorrhagic transformation, in-hospital mortality, 3-month modified Rankin scale (mRS), the National Institutes of Health Stroke Scale (NIHSS) discharge score, and duration of hospitalization were compared. We enrolled a total of 12 patients, and the cohort showed poor outcomes including 4 (33%) END events, 7 (58%) hemorrhagic transformations, 3 (25%) in-hospital mortality cases, and 7 (58%) poor mRS (3–6) scores. Additionally, the cryptogenic stroke group (n = 6) more frequently had high mRS scores (P = 0.043) as well as tendencies for frequent END events, hemorrhagic transformations, in-hospital mortality cases, and higher discharge NIHSS scores without statistical significance. In conclusion, ischemic stroke patients with active cancer, especially those with a cryptogenic mechanism, showed poor clinical outcomes after use of IV t-PA. Hindawi 2017 2017-06-04 /pmc/articles/PMC5474258/ /pubmed/28660209 http://dx.doi.org/10.1155/2017/4635829 Text en Copyright © 2017 Ki-Woong Nam et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Nam, Ki-Woong Kim, Chi Kyung Kim, Tae Jung An, Sang Joon Oh, Kyungmi Ko, Sang-Bae Yoon, Byung-Woo Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer |
title | Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer |
title_full | Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer |
title_fullStr | Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer |
title_full_unstemmed | Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer |
title_short | Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer |
title_sort | intravenous thrombolysis in acute ischemic stroke with active cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474258/ https://www.ncbi.nlm.nih.gov/pubmed/28660209 http://dx.doi.org/10.1155/2017/4635829 |
work_keys_str_mv | AT namkiwoong intravenousthrombolysisinacuteischemicstrokewithactivecancer AT kimchikyung intravenousthrombolysisinacuteischemicstrokewithactivecancer AT kimtaejung intravenousthrombolysisinacuteischemicstrokewithactivecancer AT ansangjoon intravenousthrombolysisinacuteischemicstrokewithactivecancer AT ohkyungmi intravenousthrombolysisinacuteischemicstrokewithactivecancer AT kosangbae intravenousthrombolysisinacuteischemicstrokewithactivecancer AT yoonbyungwoo intravenousthrombolysisinacuteischemicstrokewithactivecancer |